According to the audio commentary on the DVD, Fox wanted to do another "Flint" movie but James Coburn turned them down.
According to an interview James Coburn did over twenty years after this film's release, Twentieth Century Fox commissioned this film almost as soon as its predecessor, Our Man Flint (1966), opened, early in 1966 (to big box-office success). However, Coburn said, the studio showed little interest in the sequel thereafter and rather threw it together, with director Gordon Douglas also showing little interest. Coburn claimed that he and stunt arranger Robert 'Buzz' Henry (credited as second-unit director) had between them directed a great deal of the finished film.
This was the final film that "Twentieth Century Fox" produced in its CinemaScope process. Later productions shot in anamorphic widescreen would use Panavision or other optics.
As Flint's just about to board his jet (with the company name clearly seen), the gray-haired, white-jacketed gentleman who greets him is founder/inventor of the jet which bears his name, William Lear (listed in the credits as W.P. Lear, Sr.). Flint even jokingly asks if the ashtray's been cleaned.
In a shot during the opening credits, Lisa takes away a movie magazine from a one of the women under a hair dryer at Fabulous Face. The cover of the movie magazine shows Fantastic Voyage (1966), also produced by Saul David.
Yvonne Craig: [ballet] Craig was a ballerina and plays one, Natasha, in the film. Craig is best known as Batgirl, a similarly athletic role on Batman (1966).