Hayley Mills was originally cast in the lead role but had to withdraw after learning she was pregnant.
The Duchess of Duke Street (1976) and the character Louisa Trotter are loosely based on the real-life career of Rosa Lewis (née Ovenden), the "Duchess of Jermyn Street," who ran the Cavendish Hotel (called the Bentinck in the series) in London, at the corner of Duke St, St. James's. When the show first aired, there were many people who still remembered her, as she lived until 1952. According to census returns, she was born in Leyton, Essex, to a watchmaker. In the series, Louisa's family name is Leyton, and her father is a clock-maker. Cavendish-Bentinck is the family name of the Dukes of Portland.
The series was originally shown in the United States on the PBS program Masterpiece (1971), with weekly introductions by Alistair Cooke.
Location filming was done at Ripley Castle in Yorkshire.
It is said that some of the scenes in "Vile Bodies" by Evelyn Waugh, in which she appears as her fictional counterpart Lottie Crump, were also inspired by the Cavendish Hotel under Rosa Lewis' management.