Santana (Aldo Sambrell) and his bandits steal a handful of gold, and Santana kills all his men in the following night while they are sleeping, so he can keep the whole gold for himself. But that was just the start for him. Years later, he lives in the disguise of the respectable businessman Burton and commits crimes on a much bigger scale: getting his hands on all the gold-mines in the area. Some owners of promising mines find an unexpected death. The old miner Thomas (Silvio Bagolini) gets a stranger (Giacomo Rossi-Stuart) and a bounty hunter (Mario Novelli) to fight for him and the other miners against Burton.
'Uccidi Django... uccidi per primo" is a shoddy piece of work from Sergio Garrone who normally shot better westerns. Occasionally, some skills show through, for example the dark, mysterious scene when Burton and the psychopathic killer Lupe (George Wang) are meeting in a cave. But there are many poorly executed scenes. See for example the scene after 5 minutes where the bandits are riding through the gate. The bag with gold is dropped by Aldo Sambrell, but he keeps riding on. Obviously, they did not want to make a second take, so the first take with this silly mistake stayed in the movie. Otherwise, it's a great role for Sambrell though who dominates the picture, whereas he often played only supporting roles in other westerns.