Minnie Driver, Orlando Bloom, and Kate Winslet all appeared in the series before they became famous.
On one episode the "current patients" board had the ingredients of a recipe for English Breakfast written on it.
Until production of "Casualty" moved from Bristol to Cardiff in 2011, a common filming location for high-speed car accidents was the "Road to Nowhere" in Yate, just north of Bristol. This is a short length of dual-carriageway road between Rodford Way and Badminton Road, part of a planned bypass around Yate, which was started in the 1970s but was never completed. Consequently it is unused by traffic and is therefore safe for dangerous stunts, but looks like a proper road.
The first season of Casualty attracted much political controversy and government condemnation because it "dared" to be critical of hospital conditions and the chronic underfunding of the National Health Service. Also the Royal College of Nursing did not like the way that some of the nurses were portrayed. Despite these initial concerns, a second season of episodes was made, partly because the scripts had already been paid for, though initially it was thought that no more would be made after that. Now, 20 years later, Casualty has become a national institution and is the longest-running BBC drama programme and the second-longest-running medical drama in the world behind America's General Hospital (1963).
Simon Fisher-Becker was a possible for the role of a fat man trapped in a bath.