Danny DeVito was Steven Spielberg's first choice for the part of Barney. DeVito felt his acting style was too gruff to properly portray Barney, and turned the part down. Subsequently, DeVito recommended Rick Moranis for the part.
Since the entire cast performed barefoot, glassware was banned from the set to prevent injuries.
The appearance of the Flintstones' sabre-toothed cat marks one of the first times for a furry CG character in a feature film. A specific, complex algorithm (for its time) had to be developed to calculate the movement of every single hair of the fur.
On Dame Elizabeth Taylor's first day onset, she was greeted with 30 bouquets of flowers, a Cartier watch, a prehistoric bowling ball with her name engraved on it, and a bottle of her Passion perfume, redesigned in Bedrock-style fashion. The same bottle appears in the film.
Mel Blanc receives a credit for the voice of Dino five years after his death. The dialogue is taken directly from The Flintstones (1960).