In modernizing the Iron Man's origin story, Tony Stark is not injured in a Vietnamese war zone, but in an act of industrial sabotage plotted by Justin Hammer and the Mandarin. Stark was wounded not by a chunk of shrapnel near his heart, but by slivers near his spine, Stark and Yinsen (whose first name is changed from Ho to Wellington) were held captive by the Mandarin, rather than Wong Chu. However the concept of the Iron Man armor keeping Stark alive was in Season 2 with getting Iron Man injured in his chest after taking a direct hit from a missile while attacking Hammer on his own property. He upgraded his armor in order to attempt to heal his chest.
Instead of the main superhero team being the obvious choice, the Avengers, which was founded by Iron Man, the series went with the short lived team lead by the Scarlet Witch, Force Works. In the comics, Force Works was created after the Avengers East Coast disbanded the Avengers West Coast, which lead to Scarlet Witch, Spider-Woman, Wonder Man and Hawkeye quitting.
Tom Tataranowicz had advocated eliminating the Stan Lee intros in the interest of more screen time for the stories. However, it was felt that Stan's vast legion of fans liked seeing him in the intros of the episodes and that not using him could frankly be interpreted as insulting to Stan. Tataranowicz realized that they were right. Thus, they did shorter Stan Lee intros with Stan "green screened" so they could place him against backgrounds from the shows. Using his previous live action experience, Rick Ungar set everything up and Tataranowicz directed Stan through the intros. Stan's energy was and is amazing, and Tataranowicz thought these came out rather well, adding nicely to both the "Iron Man" series.
In the original comics War Machine had various additional weapons such as an automatic Gatling gun and a missile launcher on the shoulders of his armor. The cartoon incarnation omits these due to them being inappropriate for a family-friendly show and instead his armor has more of a resemblance to Iron Man's armor aside from the color difference.
Tony Stark's main armor on the show was the "Mark XI "Modular Armor", which was the suit he was wearing in the mid 90's comics. The first season modified his helmet design to add a traditional mouth slit, but the second season restored the "mouthless" comic book design.