I've been a fan of Bill Plympton since I first saw one of his shorts in a late-80s animation festival, and to me, "I Married a Strange Person!" is his best work. It's possible that I've missed something better -- I've seen many/most of his shorts, but only one other of his long-form works, "The Tune". This film, to me, is much funnier and more memorable than "The Tune", though not as deep, I suppose.
Fans of the "splatstick" horror/comedy genre should enjoy this film, as it uses over-the-top gore to similar comedic effect. Don't get the impression that this is a film in the vein of "Lupo The Butcher" or something, though, with ultra-violence being used for ultra-violence's sake. Plympton's imagination is FAR too vivid for that to be the case.
I'd have to say, in fact, that Plympton has the most unique and active imagination of any visual artist I'm familiar with, and this film is a great showcase for it, since the plot concerns a special brain lobe that causes imagination to become reality.
Apart from the comedic gore, there are hilarious looks at sex. What Plympton has done for quitting smoking and other topics in his shorts, he does here for sex. Everything from people to animals to inanimate objects are seen engaging in the act here, to comic effect. One of the most imaginative images is the upper receptacle in an electrical outlet banging the lower receptacle from behind (with the three-prong receptacles having become faces).
Another thing to mention is the film's great score. Funny, catchy, toe-tapping tunes that you'll feel like you've heard somewhere before.
To sum up, buy this film! If you're at all a fan of animation or semi-risque comedy, you're sure to love it.