Val Kilmer prepared for his role by studying with a sculptor friend of his in New Mexico who had lost his sight in Vietnam. At 49:30 (NTSC) he is admiring a sculpture when he first visit's Amy's flat.
There have been several references to Val Kilmer in Friends (1994), with the most notable being when Ross rented Kilmer's jacket that he wore to the premiere of this movie.
Cast member Drena De Niro is the daughter of Robert De Niro, who also played a fictionalized patient of Oliver Sacks in Awakenings (1990).
Dr. Oliver Sacks, the author of the story on which this movie is based, has a small credited role as a reporter at Virgil's speaking engagement.
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