According to Omar Epps in several interviews, In Too Deep is based (loosely) on the true story of an undercover police officer who infiltrated an inner-city drug empire and took down the crimelord in charge. The undercover cop later committed suicide as a result of being "in too deep" in his undercover character role within the criminal organization.
LL Cool J & Omar Epps later starred in the 1st episode of the 2nd season of House (2004) called Acceptance; LL Cool J played a Death Row inmate.
Pam (Veronica Webb), the wife of LL Cool J's character was also featured on his 1989 album cover for "Walking With A Panther".