The production team came up with the principal designs of the game's areas by building miniatures out of Lego.
During the battle with Psycho Mantis if you go into First Person mode, you'll actually see the game through his eyes.
If you reach the last stall of the women's bathroom in less than five seconds after Meryl runs into the bathroom, she won't be wearing any pants in the next scene.
David Hayter (Snake) and Doug Stone (Psycho Mantis) were the only members of the English voice cast that were not credited under pseudonyms. The rest of the cast used aliases because they were not sure if the project was Union-sponsored or not.
The PlayStation version of this game has sold 6.6 million copies worldwide.