Overlord sends his monstrous spider-like assassin, Arachnid, to abduct Dragon's police partner Alex and mentor Frank in an attempt to blackmail Dragon to join his force of evil mutants. Dragon also deals with a media smear campaign.
Dragon takes young, good-natured, delinquent mutant called Barbaric on a police ride-along to straighten him out, but mysterious Horde and his mind-controlling leaches possess the cops and turn Barbaric into an unstoppable behemoth.
Alex goes undercover as a costumed "freak" named Red Talon and befriends Overlord's brutish shark-like lieutenant, Mako, in order to infiltrate Overlord's gang, the Vicious Circle, and thwart their plan to poison the city water supply.
Overlord's henchmen Open Face and Octopus steal experimental quantum magnetics technology to create Dragonsmasher, a large robot programmed to destroy Dragon. Dragon also deals with a shady congressional candidate.
Overlord breaks Mako and his gang out of prison to hijack a train that Alex happens to be on and use it to blow up the city's new train tunnel. Dragon is forced to work on the case with his bigoted colleague, Sgt. Niceman.
When Dragon's overly enthusiastic fan and younger female equivalent, the She-Dragon, botches a police sting, the two Dragons must team up to save Alex from Mako's gang and stop Overlord from using a supermicrochip to take over the city.
Alex is hurt while trying to stop Lowblow and his hulking partner, Bludgeon, who rob banks for Overlord. Alex's bigoted new boyfriend blames Dragon for this, especially after Bludgeon goes after immobile Alex to get back at Dragon.
Dragon arrives in Hospitality, a small southern town run by a bigoted sheriff, to find out what Overlord's henchmen, Basher and Doubleheader, are doing there. What he finds is Arachnid's insatiable hunger.
Dragon is tasked to protect John Smith, a progressive mutant politician running for Mayor of Chicago, but Overlord creates Dragon's evil robot clone and sends it to assassinate Smith.
Dragon finally manages to apprehend Overlord, but the crime lord orders Bludgeon to kidnap Barbaric's spunky kid sister (who is not a mutant), forcing the good mutant to help him take revenge on Dragon.
The Fiend, a demonic entity which feeds on hate, possesses Sgt. Niceman and attacks mutants. Dragon stops Niceman's rampage but Niceman presses charges. Meanwhile, a self-help guru who hates his gullible fans becomes Fiend's next host.
Dragon puts She-Dragon in protective custody at Barbaric's place after she tries taking on a rampaging female mutant biker gang consisting of Volcanic, Vein and their leader with a maw for a stomach, Ma.
A mad scientist resurrects the Horde and uses his science team's global warming research to bring about apocalyptic climate change fit for leeches. Can Dragon, Alex and She-Dragon stop him in time?
