A lot of animes set people off. Slow beginnings, long series, and lack of substance make a lot of anime shows completely unwatchable to the newcomer.
Those animes should take a lesson from Trigun. If there was ever an anime that told a story best in 26 episodes, it's definitely this one. Vash The Stampede, a supposed outlaw with a $$60 million reward, must set out to find where his life started and how to go on now. On his journey he is tagged along by reporters Meryl Stryfe and Milly Thompson, and is later accompanied by the gun-toting priest Nicholas D. Wolfwood.
Every episode has its own wonderful story and solves a little more of the mystery of Vash's life, always wanting you hungering for more but feeding you enough to love that episode just as much as any other. I, for one, was very able to connect to the characters as each has their own colorful and lovable personality. It brought a lot of life to an anime series that you aren't treated to often.
There's no way you can't enjoy Trigun - it's an anime series for all and definitely one that will last throughout anime history as one of the best. It may not be glittered with massive CG and high-budget animation, but that's not what is important. If you haven't seen this yet, go see it now.