First-day-on-the-job publicist Mark Clock has the assignment of a lifetime: to pick up A-list Brad Beau Hodges (modeled after Brad Pitt) and, while avoiding paparazzi, safely escort the celebrity to his own surprise birthday party in Malibu. The mission goes sour when Brad accidentally drinks a Coke containing roach repellent at a nuclear-power plant in Sun Valley, California. The plant supervisor Bear (modeled after Kid Rock) suggests taking him to the nearest supermarket to purchase a laxative to relieve his Planet of the Apes hallucinations from the poisoned soda. The two elect to stop at Mark's psychiatrist, Dr. Rosenblum, first; the doctor takes control by declaring himself the designated driver, but he has his own agenda: to drive to Compton to aid his crack addiction. In the heat of panic, Mark is accompanied by a strange entourage including a pimp from the ghetto. The entourage escorts the delusional Brad to his surprise birthday party in Malibu. The real heat is laid on Mark when his psychiatrist lures young makeup artist Fancy into a bedroom for sex and drugs. She overdoses, and Mark's bizarre crew, now led by Toto, head out to bury her in the Barstow Desert. After that, one of the most bizarre situations ever captured in a motion picture will go down.
—David Fitzjerald