Michael Seater (Lucas Randall) and Robert Clark (Vaughn Pearson) both previously starred in The Zack Files (2000), in which they played Spencer Sharpe and Zack Greenburg respectively.
Emma Taylor-Isherwood (Josie Trent), Shadia Simmons (Corrine Baxter), Michael Seater (Lucas Randall) and Jeff Douglas (Professor Noel Zachary) are the only actors to appear in all 42 episodes of the series. In second place is Noah Reid (Marshall Wheeler), who appeared in every episode except for Conclusions: Part 2 (2006).
Tony Munch originally auditioned for Professor Zachary.
In the episodes that show Josie's bedroom, you can see a SpongeBob poster on the wall.