Some of the interiors of the cruise liner (especially the grand staircase) are based on the first class interior design of R.M.S. Titanic.
The ship in the game, the "Spencer Rain" is a reference to Ozwell Spencer, the man who created Umbrella.
The box art for the game has an error. The game summarization has labeled the main characters' name as "Bruce MacGavin" when in the game, it's actually "Bruce McGivern".