The babies are named for the actors who portray them Baby Patrice was named so because Patrice O'Neal would be providing the voice. Baby Nick was named because Nick Di Paolo would be providing the voice. The babies also bear some resemblance to their namesakes.
Originated as a series of commercials on Comedy Central featuring animated versions of clips from various stand-up acts.
In one of the comedy clips, the comedian begins to talk about firefighters and a non-animated picture of a firefighter appears on screen. The picture is of Denis Leary's character on the FX show Rescue Me. Leary is an executive producer of Shorties.
In the animation for Elon Gold's "Theo Awards" the show's producers appear as animated characters seen partaking in various narcotic substances.
'Nick Dipaolo' originally auditioned for the part of Baby Patrice.