Wayne Grayson
- Joey Wheeler
- (voice)
- …
Gregory Abbey
- Tristan Taylor
- (voice)
- (as John Campbell)
Amy Birnbaum
- Téa Garnder
- (voice)
Madeleine Blaustein
- Solomon Muto
- (voice)
- (as Maddie Blaustein)
Marc Thompson
- Duke Devlin
- (voice)
James Carter Cathcart
- Weevil Underwood
- (voice)
- (as Jimmy Zoppi)
Sam Riegel
- Rex Raptor
- (voice)
- (as Sam Regal)
Ted Lewis
- Bandit Keith
- (voice)
- (as Ed Paul)
- …
Tara Sands
- Mokuba Kaiba
- (voice)
- (as Tara Jayne)
Jonathan Todd Ross
- Marik Ishtar
- (voice)
- (as JT Ross)
- …
J. David Brimmer
- Odion Ishtar
- (voice)
- (as Michael Alston Baley)
Nell Balaban
- Ishizu Ishtar
- (voice)
- (as Karen Neill)
Eric Stuart
- Seto Kaiba
- (voice)
Andrew Rannells
- Mako Tsunami
- (voice)
- (uncredited)
Erica Schroeder
- Dark Magician Girl
- (voice)
- (uncredited)