The first Transformers series since Transformers: Armada (2002) to not use CGI to represent the robotic characters.
John Moschitta Jr., the original voice actor of the fast-talking Autobot Blurr returns to reprise his role again. Although this time Blurr actually speaks coherently. In The Transformers (1984), the original Blurr often simply repeated his lines.
This is the first, and so far only, Transformers continuity family in which the rank of Prime isn't the highest in the Autobot Army.
Voice actor David Kaye, after more than a decade of playing the role of the evil antagonist Megatron, gets to voice the heroic main protagonist Optimus Prime in this series. He also auditioned for Megatron, but the sudden switch, he reports, was completely unexpected even to him. When he was offered the role, he responded, "Are you sure?" He admitted that he had trouble finding the character in the first few episodes. He is the second actor to have voiced both Optimus Prime and Megatron, after Garry Chalk.
Art director and character designer Derrick Wyatt is one of the few official Hasbro employees who had already been Transformers fans even before being employed by the company.