Juanita (Eugene Domingo) barely escapes her mother-in-law's wrath. Maria (Debraliz) also puts a curse on Juanita and one of her daughters, Julia Rose (Ai-Ai de las Alas), the curse was that they will encounter a lifetime of Bad Luck. But Maria blesses the other daughter, Jenny Rose (Rufa Mae Quinto) with good fortune. Series of appalling events and revelations unfold as their lives intertwine.