This was my least favorite film I saw at Sundance (Fire of Love was probably my favorite). I'm guessing the source material was interesting enough, so it's too bad it turned out this way. I can understand why the topic would impress festival critics. I'm also really glad to see more trans films coming out over the last few years (all the other ones I've seen were better than this one).
I have to be honest though, I mostly agree with the other review that says this could have been a much better film than the one that was screened. The problem is the way that Framing Agnes tells its story is confusing, and not in a way that pays back interpretation beyond what the film already tells you about itself. The pacing was off too. And it wasn't visually exciting. Somehow a 75-minute feature felt like it dragged for over 2 hours. At parts, this felt like a student film, its heart is in the right place but it fails -- and not in an interesting way.
Also I'm also a fan of reenactments and experimental fiction elements in documentaries. For a couple of decades I've seen many films blur history and fiction. Maybe the most creative and stunning and well known example was The Act of Killing. Framing Agnes tries to use reenactment to produce a counternarrative to the representation of trans people in history, on TV, and other contexts. In theory that's a promising idea. In practice it doesn't work well. What the film does just isn't as new as at least one of the reviews I read claimed. A couple of the performances are really strong, which is why I'm higher on this than the other reviewer even though I agree about the director's awkward performance. Still, the reenacted segments are both poorly integrated and the writing is mostly flat. The takeaways about trans people might have been more surprising or meaningful 10 years ago than they are now. I'm sure this film will win festival awards but I can't see it finding an audience beyond a smaller group of people who want to see a film that unfortunately isn't there.