The "real" Dr. Abigail Tyler was played by the actress Charlotte Milchard. In the end credits she appears credited as Dr. Abigail Tyler and in the final cast list with her real name but as one of the "Nome Resident".
"The Fourth Kind" is a reference to scientist J. Allen Hyneks famous categories involving the sightings of UFOs. Close Encounters of the Third Kind (1977) also referred to this scale.
The movie's hoaxed interviews have angered the families of real missing persons in and around Nome, Alaska, for trivializing their loss. Melanie Edwards, Vice President of Kawerak Inc. (an organization representing tribal peoples in Alaska), described the movie as "insensitive to family members of people who have gone missing in Nome over the years". Universal has refused to discuss the movie with that organization or with local journalists.
The end credits do not include the usual "The events and persons depicted in this film are fictitious..." or "The film is based on the real events..." section.
The screenplay for this film was featured in the 2008 Blacklist; a list of the "most liked" unmade scripts of the year.