A fading celebrity takes a black-market drug: a cell-replicating substance that temporarily creates a younger, better version of herself.A fading celebrity takes a black-market drug: a cell-replicating substance that temporarily creates a younger, better version of herself.A fading celebrity takes a black-market drug: a cell-replicating substance that temporarily creates a younger, better version of herself.
- Awards
- 8 wins & 23 nominations
Edward Hamilton-Clark
- Fred
- (as Edward Hamilton Clark)
- Director
- Writer
- All cast & crew
- Production, box office & more at IMDbPro
Storyline
Did you know
- TriviaRay Liotta was cast in the film in February 2022, but he died in May that year before he could film his scenes. Dennis Quaid replaced him, but Liotta is still mentioned in the director's "Thank You Notes" during the credits.
- GoofsThe toilet mirror reappears intact after being repeatedly smashed during the fight sequence.
- Quotes
Elisabeth Sparkle: There's been a slight misuse of the Substance.
- Crazy creditsA special thanks in the credits is given to the many extras in the theater scene, who got covered in blood.
- ConnectionsFeatured in The Project: Episode dated 20 September 2024 (2024)
- SoundtracksPump It Up
Written by Michael Hall, Leonardo Stella
Performed by Earl Gregory
Produced by Julien Deguines
Featured review
Every scene of this film wowed me at TIFF. The casting, atmosphere, visual and sound design, music, and, of course, the symbolism of it all.
Demi Moore and Margaret Qualley couldn't have been more perfectly cast as leads. Their devotion to the process and trust in their director was clear to me. Their vulnerability pulls this off and leads to a very compelling fever dream.
Everyone involved should be really proud of this film. To me, it's a future cult classic.
It is body/psychological horror, so don't expect jump scares. It's deeper than that. I found myself getting lost in reflection during the film (as a 47 year old woman it really spoke to me).
But it's also extremely fun to watch!
Take it seriously as a true work of art, but don't at the same time, and you'll have a blast.
Demi Moore and Margaret Qualley couldn't have been more perfectly cast as leads. Their devotion to the process and trust in their director was clear to me. Their vulnerability pulls this off and leads to a very compelling fever dream.
Everyone involved should be really proud of this film. To me, it's a future cult classic.
It is body/psychological horror, so don't expect jump scares. It's deeper than that. I found myself getting lost in reflection during the film (as a 47 year old woman it really spoke to me).
But it's also extremely fun to watch!
Take it seriously as a true work of art, but don't at the same time, and you'll have a blast.
- julie-ford
- Sep 6, 2024
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Details
- Release date
- Countries of origin
- Official site
- Language
- Also known as
- Thần Dược
- Filming locations
- La Maison du Caviar - 21 Rue Quentin Bauchart, Paris 8, Paris, France(Elisabeth and Harvey at the restaurant)
- Production companies
- See more company credits at IMDbPro
Box office
- Budget
- $17,500,000 (estimated)
- Gross US & Canada
- $16,381,350
- Opening weekend US & Canada
- $3,205,212
- Sep 22, 2024
- Gross worldwide
- $55,437,207
- Runtime2 hours 21 minutes
- Color
- Sound mix
- Aspect ratio
- 2.39 : 1
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