You can optionally or unintentionally go through the entire game without a radio, a first for the series. The first game in the franchise to not feature a radio (for gameplay purposes) is Silent Hill 4: The Room.
In Patrick Wearden's house (Sidequest "Scatter their ashes at their special place"), Murphy dies by simply looking too long at the books showing children's drawings, to be found on the couch in the living room. If you press 'Zoom' and look closely at the books for about 10 seconds and then try to move on, Murphy goes down dying from a heart attack.
In Pearl Creek at Lansdale Avenue, Murphy can visit Henry Townshend's apartment from Silent Hill 4: The Room.
Ironically Murphy's "blind fire", where the player shoots a firearm without using the manual aiming mechanics, is 100% accurate. Murphy will 100% always deadeye hit an enemy that is in sight if the player blind fires. This is possibly a bug that wasn't caught during testing, and was never fixed with a patch after the game's release.
If the player puts money in the jukebox at the Devil's Pitstop diner, it will play the original Silent Hill theme song, heard in the opening FMV of the original game. This is also the song that DJ Ricks plays when he and Murphy meet.