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Comedian John Pinette was found dead at age 52 in his hotel room in Pittsburg on Saturday, April 5.

According to the medical examiner, Pinette died of natural causes related to “a medical history he was being treated for." According to the New York Daily News, Pinette was being treated for liver and heart disease.

Pinette earned a place in history in 1998 when he appeared as Howie, the victim of a carjacking in the Seinfeld series finale, but he was also a successful and beloved stand-up comedian and was still touring at the time of his death.

Friends and comedians took to Twitter to express their grief over the loss.

The world has lost a truly funny person. Rest in peace John Pinette.

— Joy Behar (@JoyVBehar) April 7, 2014

Never worked with John Pinette; never heard a bad word about him. And he Loved being a comedian. He got dealt a good life. #Rip...

Stand up comedian and actor John Pinette died Saturday in Pittsburgh after suffering a pulmonary embolism, his manager of 24 years Larry Schapiro confirms. He was 50. Pinette, a veteran of the comedy club circuit who underwent treatment for prescription drug addiction last year, was found dead in his hotel room yesterday afternoon. No autopsy was conducted. Pinette’s feature film credits include ’90s comedy films Reckless Kelly, Junior, and Simon Sez as well as Duets, The Punisher, Rio Sex Comedy, and Hyung-rae Shim’s The Last Godfather. On the small screen, Pinette was a regular on Parker Lewis Can’t Lose and appeared on Vinnie & Bobby, High Tide, and on the series finale of Seinfeld. His comedy special John Pinette: Still Hungry premiered on Comedy Central in 2011. At the time of his death the L.A.-based comedian was touring and developing his next stand-up special, titled John Pinette: They Call Me Slim.