When Tammy and Pearl are in the diner, the celery sticks in the Bloody Mary's keep changing position in almost every shot.
When Tammy leaves the diner w/ the car keys, her glass changes from half to totally full between shots.
When Tammy is being fired, her bag changes from one side to the other by the look of the strap.
When Tammy after getting fired and starts to abandon her car; she grabs her bag with her left hand and her boombox with her right. However in the next immediate cut after she exits the car; the bag is now on her right shoulder and her left hand is holding the boombox.
In the beginning when Tammy is getting fired, pay close attention to Ben Falcone's tie clip. Sometimes it's crooked and sometimes it's not.
When the bounty hunter catches Tammy and throws her in the back, there is a big black lock on it. When they drive away it is not there.
When Tammy goes back to rescue her grandmother from the nursing home, they are supposed to be in Illinois but all of the vehicles in the parking lot have Kentucky license plates.
When Tammy and Pearl enter the Bar in what is supposed to be Louisville, Kentucky, you can clearly see the North Carolina Flag flying in the background, as this movie was filmed almost entirely in eastern North Carolina.
When Pearl and Tammy are arrested the judge sets her bond at $3000, and the police officer tells Tammy that she must come up with that amount to get Pearl out. In reality most bondsmen will bond you out for 10-15% of your bond, making it roughly $300-450 to get Pearl out.
The police officer mentions the Cadillac being a 2004 DeVille. However, the model shown in the movie is either a 1998 or 1999.
Keith Morgan Tammy's boss tells Tammy she was at least 40 seconds fired. She was actually fired 35 seconds by the time Keith told her this.