The second time that brothers Ridley Scott and Tony Scott have produced a remake of a project involving Michael Crichton. Previously, they produced The Andromeda Strain (2008).
Lead actress Lauren Ambrose was actually born in the same year that the original film version of Coma (1978) was made.
Dedicated to executive producer Tony Scott who committed suicide only weeks before the mini-series was first broadcast.
The facility used for the Jefferson Institute is Georgia's own High Museum of Art in Atlanta Located on Peachtree Street in Midtown, the city's arts district. Also colloquially known as "the High", the High is a division of the Woodruff Arts Center.
The James Woods character, "Howard Stark," has the same name as Tony "Iron Man" Stark's father.