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LOST tells the story of a series of women-women who are out of place, regretful of their past, dissatisfied with their present, and disillusioned with their future. The protagonist is Julia, a woman who flirts with old age, regrets the many mistakes she made years ago, and decides to commit suicide when she learns she has Alzheimer's. Meanwhile, Julia's daughter, Marina, constantly blames her mother for her father's death. This peculiar world is completed by characters like Candela (a woman desperately seeking someone to love her, only to end up with nights filled with loveless sex), Catalina (a former film star turned cocaine addict), and a group of teenagers whose personal relationships are marked by parental neglect and the influence of the media.

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