Most of the shots of the large crowds were footage from One Direction concerts.
The real-life rappers (50 Cent, Diddy, Nas, etc.) talking about their love for Style Boyz were not scripted. Their responses were based on questions asked by The Lonely Island as if it were about the real-life rap group Beastie Boys.
In this movie, Seal says he got the scars on his face from wolves. In real life, he got the scars from lupus, an autoimmune disease. The scientific name for wolves is "Canis lupus".
The character of Hunter the Hungry is believed to be a loose parody of the rapper Tyler the Creator.