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Linezolid: Usage and Safety Guide

Linezolid is an expensive antibiotic available as injections, tablets, or oral suspension that is reserved for multidrug-resistant infections. It is used in hospitals due to risks of bone marrow suppression, peripheral neuropathy with long-term use, and increased blood pressure when combined with certain drugs. Linezolid inhibits bacterial protein synthesis and is effective against gram-positive bacteria like methicillin-resistant Staphylococcus aureus.

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Mohamed Abbas
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129 views1 page

Linezolid: Usage and Safety Guide

Linezolid is an expensive antibiotic available as injections, tablets, or oral suspension that is reserved for multidrug-resistant infections. It is used in hospitals due to risks of bone marrow suppression, peripheral neuropathy with long-term use, and increased blood pressure when combined with certain drugs. Linezolid inhibits bacterial protein synthesis and is effective against gram-positive bacteria like methicillin-resistant Staphylococcus aureus.

Uploaded by

Mohamed Abbas
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PDF, TXT or read online on Scribd
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- It is available in the form of injections, tablets and an oral suspension.

(All are expensive.)


- Bone marrow suppression and peripheral neuropathy are sometimes observed general - Therapy with linezolid is reserved for multidrug-resistant infections and should
with prolonged therapy (more than 14 days) and regular haematological and be commenced in hospital.
neurological monitoring are recommended.
- Due to its monoamine oxidase inhibitory activity, blood pressure can increase
adverse mechanism
when linezolid is used in combination with dopamine, adrenaline, serotonergic - Linezolid inhibits an early step in bacterial protein synthesis.
drugs (eg selective serotonin reuptake inhibitors, monoamine oxidase inhibitors, effects linezolid of action
tramadol, pethidine), pseudoephedrine, and foods with a high tyramine content.
- There have been reports of serotonin syndrome and coadministration with
serotonergic drugs should be avoided. - It is effective against Gram-positive organisms, including methicillin-resistant
spectrum strains of Staphylococcus aureus, coagulase-negative staphylococci, VRE,
of action and penicillin-resistant strains of Streptococcus pneumoniae.

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