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Nano-Emulsion: Advantages and Disadvantages Preparation Stability Sign Application

Nano-emulsions are fine dispersions of immiscible liquids with droplet sizes between 20-500 nm. They offer advantages over traditional emulsions like improved absorption and stability. Nano-emulsions can be prepared using high- or low-energy methods and offer flexibility in formulation. They have a variety of applications including as antimicrobial agents, in enzyme replacement therapy, cancer treatment, and vaccinations where their small size allows active ingredients to be effectively delivered. Nano-emulsions are also used in cosmetics due to their sensory and biophysical benefits like rapid penetration and hydration.

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232 views10 pages

Nano-Emulsion: Advantages and Disadvantages Preparation Stability Sign Application

Nano-emulsions are fine dispersions of immiscible liquids with droplet sizes between 20-500 nm. They offer advantages over traditional emulsions like improved absorption and stability. Nano-emulsions can be prepared using high- or low-energy methods and offer flexibility in formulation. They have a variety of applications including as antimicrobial agents, in enzyme replacement therapy, cancer treatment, and vaccinations where their small size allows active ingredients to be effectively delivered. Nano-emulsions are also used in cosmetics due to their sensory and biophysical benefits like rapid penetration and hydration.

Uploaded by

syarifa
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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Download as PDF, TXT or read online on Scribd
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NANO-EMULSION

• Definition
• Advantages and
disadvantages
• Preparation
• Stability sign
• Application
NANO-EMULSION

 Emulsion is fine dispersion of an immiscible


liquid into another liquid in form of small
droplets
 Nano-sized emulsions with the average
droplet size falls between 20–500 nm.
 Thermodynamically and kinetic stable
 Improving the delivery of active A) Nanoemultion solution
pharmaceutical ingredients
B) Macroemultion solution
Greater
Non-toxic
absorption

Stabilization depends on Surfactant must be non-


Improved amounts of surfactant and toxic to ensure safety for
Variety of pharmaceutical
physical co surfactant
formulation application
stability

Protect drugs
from hydrolysis
and oxidation
Oil in water nano- Water in oil nano-
emulsion emulsion
High • Ultrasonic emulsification
• High pressure
Energy homogenization
• Oil
• Emulsifying agent
• Aqueous phase
Low • Phase inversion
temperature
Energy

• Surfactant selection
• Concentration of surfactant
• Flexibility of surfactant
Instability sign of Nano-
emulsion

• Flocculation consists of the joining together


of globules to form large clumps or floccules
• Creaming is process by which the disperse
phase separates from an emulsion
• Sedimentation is when the droplets sink to
the bottom of the solution
• coalescence, the droplets merge into each
other to become a bigger drop
• Ostwald ripening due to the difference in
chemical potential of solute within droplets of
different sizes.
• Phase separation is a separation of the
dispersed phase
Application
Nano-emulsion
Application In Pharmaceutical
• Antimicrobial agent Anti-microbial
• Enzyme replacement therapy in the liver Product
• Treatment of cancer • Activity of antimicrobial
• Vaccination. ingredient

• Electrostatic attractions
Fusion of nanodroplets with the
pathogen cells results in releasing
a part of the energy trapped
within the emulsion and therefore
cell lysis.
Oil in water Nano-emulsions become attention in the cosmetic
industry, especially in the field of skin care, for two main reasons:
1. Sensorial features, such as rapid penetration as a result of their nano sizes, and
their merging textures.
2. Biophysical features, such as hydrating power

Hair
Skin Anti-aging Sunscreen
treatment
moisturizer product product
product

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