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Rat Use in Pharmacology Studies

The document discusses characteristics and uses of rats in experimental pharmacology. Rats are warm-blooded rodents commonly used as they cannot vomit and lack a gallbladder, making them suitable for screening drugs. Specific strains used include albino, Wistar, Sprague-Dawley, and others. Rats are omnivorous and resistant to cardiac glycosides. They are used for psychopharmacological, analgesic, and hormonal studies as well as studies of estrus cycle, isolated tissues, blood pressure, and gastric acid secretion.

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tayyab malik
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68 views1 page

Rat Use in Pharmacology Studies

The document discusses characteristics and uses of rats in experimental pharmacology. Rats are warm-blooded rodents commonly used as they cannot vomit and lack a gallbladder, making them suitable for screening drugs. Specific strains used include albino, Wistar, Sprague-Dawley, and others. Rats are omnivorous and resistant to cardiac glycosides. They are used for psychopharmacological, analgesic, and hormonal studies as well as studies of estrus cycle, isolated tissues, blood pressure, and gastric acid secretion.

Uploaded by

tayyab malik
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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Experiment no:

Animal handling (Rat)

Rat

(Adult weight 200-250)

Biological name

Rattus Norvegicus

Common strain used

Albino rats of wistar strain, Sprague-Dawley, Wister Kyoto, Lewis and Porton.

Specific Characteristics

Rat is a warm blooded rodent. It can’t vomit and does not possess the vomiting center. It has no tonsil
and gallbladder in its body. Hence it can’t be used in the screening of the drugs having activities on
vomiting center or gallbladder. Rat is omnivorous animal. It shows resistance to the effects of cardiac
glycosides.

Use in the experimental pharmacology

Psychopharmacological studies

Study of analgesics and anticonvulsants.

Bioassay of various hormones such as insulin, oxytocin, vasopressin etc.

Study of estrus cycle, mating behavior and lactation.

Study on isolated tissue preparations like uterus, stomach, vasdeferens, anoccoccyggeus muscle, fundus
strip, aortic strip, heart rate etc.

Chronic study on blood pressure.

Gastric acid secretion studies.

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