Asia Pacific College of Advanced Studies
College of Nursing
                                                A.H. Banzon St. Ibayo, City of Balanga, Bataan
        CASE STUDY
Definition ( Pls. provide a picture)
Nephrotic syndrome is the most common presentation of
glomerular injury in children. It is defined as massive proteinuria,
hypoalbuminemia, hyperlipidemia, and edema, but the disorder is
a clinical manifestation of a large number of distinct glomerular
disorders in which increased glomerular permeability to plasma
protein results in massive urinary protein loss.
Causes
Most children with this problem have idiopathic nephrotic syndrome. Idiopathic means that it occurs with no known
cause.
In rare cases, a nephrotic syndrome may occur in the first week of life. This is called congenital nephrotic syndrome. It is
inherited by an autosomal recessive gene. This means that boys and girls are equally affected. A child inherits 1 copy of
the gene from each parent, who are carriers. Carrier parents have a 1 in 4 chance of having a child with this syndrome
with each pregnancy. The outcome for this type of nephrotic syndrome is very poor.
Many possible causes
Diabetic kidney disease, Minimal change disease, Focal segmental glomerulosclerosis, Membranous nephropathy,
Systemic lupus erythematosus, Amyloidosis
Pathophysiology ( Diagram format)
Sign & Symptoms
The signs and symptoms of childhood nephrotic syndrome may include
     Edema—swelling, most often in the legs, feet, or ankles and less often in the hands or face
     Albuminuria—when a child’s urine has high levels of albumin
     Hypoalbuminemia—when a child’s blood has low levels of albumin
     Hyperlipidemia—when a child’s blood cholesterol and fat levels are higher than normal
In addition, some children with nephrotic syndrome may have
     Blood in their urine
     Symptoms of infection, such as fever, lethargy, irritability, or abdominal pain
     Loss of appetite
     Diarrhea
     High blood pressure
Laboratory/ Diagnostic Exams
       Urine tests.  A urinalysis can reveal abnormalities in your urine, such as large amounts of protein. You might be
        asked to collect urine samples over 24 hours.
       Blood tests.  A blood test can show low levels of the protein albumin and often decreased levels of blood
        protein overall.
       Kidney biopsy. During a kidney biopsy, a needle is inserted through your skin and into your kidney. Kidney
        tissue is collected and sent to a lab for testing.
Medical (Pharmacologic) Management
Treatment will depend on your child’s symptoms, age, and general health. It will also depend on how severe the
condition is.                                                                                 
Medicines may be used to treat initial symptoms and relapses. These may include:
     Corticosteroids
     Immunosuppressives
     Diuretics to reduce the swelling
Surgical Management ( if applicable)
      The role of surgery in nephrotic syndrome is not directed for patients with primary causes, but only as
       supportive or symptomatic care. Surgery has some role in nephrotic syndrome patients with secondary
       etiology, which will be mentioned below separately.
Three Nursing Diagnoses
      Excess fluid volume
      Risk for infection
      Imbalanced nutrition: Less than body requirements
Nursing Management
      Strictly monitor and record of input and output
      Advised to limit fluid intake
      Administer medication as prescribed
      Encourage high  potassium, low-fat, low sodium diet with moderate amounts of protein.
      Monitor client’s weight daily (using the same scale with the child in the same clothing at the same time of the
       day).
      Advise parents to immediately notify the physician of sign or symptom of infection.
       Prepared by:                                                    Checked by:
       Santos, Lore Anne Mhae                                          Giovanni D. David, EdD, RN
       Student Nurse                                                          Instructor