REVERSIBLE and IRREVERSIBLE CELL INJURY
A. Normal kidney tubules
B. Early (reversible) ischemic injury w/ blebs, increased eos, swelling of
some cells
C. Necrosis (irreversible) injury: loss of nuclei, fragmentation of cells
Kidney Tubule, cellular swelling
NORMAL
CELLULAR
SWELLING
CELLULAR
SWELLING
HPO; tubules with dilated epithelial cells, reduced
*PPT NI DOC laminal size (VACUOLATIONS)
NECROTIC CELLS
- preserved outlines
w/ loss of nuclei and
infiltrates
NORMAL
A. Coagluative Necrosis
B. Edge of infarct
• localized area of coagulative necrosis is called an INFARCT
LIQUEFACTIVE NECROSIS
- digestion of dead cells
- tissues becomes liquid
- seen in focal bacterial
or fungal infxn
- may pus daw pero wala
naman dito sa picture
amp robbins
FAT NECROSIS
- white chalky deposits
→ saponification
- result from release of
PANCREATIC LIPASES
- parang mais yummy
- seen in ACUTE
PANCREATITIS
CASEOUS NECROSIS
- TB of the lung
- contains yellow-white
and cheesy appearing
debris
- eden who
FIBRINOID NECROSIS
- artery toh
- wall: bright pink in ur
necrotic area~ (fibrinoid) w/
inflammation ehe
- vascular damage caused by
deposited complexes of
antigens and antibodies
APOPTOSIS
A. epidermal cell apoptosis
B. apoptosis with compacted
chromatin
C. blebbing and apoptotic
bodies, fragmentation,
and activation of caspase
3
HYPERTROPHY OF UTERUS
A. gravid uterus
B. normal uterine smooth muscle
C. large plumps of cells from gravid uterus (same mgnfctn as b)
ATROPHY
NORMAL ATHEROSCLEROTIC
CEREBROVASCULAR DISEASE
METAPLASIA; columnar → squamous
FATTY LIVER
FATTY LIVER (Steatosis)
FAT VACUOLES
FAT VACUOLES
PORTAL TRIAD
FAT VACUOLES
*PPT NI DOC
CHOLESTEROLOSIS
Cholesterol-laden
macrophages
PROTEIN REABSORPTION DROPLETS
BROWN ATROPHY
LIPOFUSCIN
GRANULES
(lipochrome)
DYSTROPHIC CALCIFICATION
OF THE AORTIC VALVE
- marked by stenosis
- semilunar cusps are
thickened and fibrotic
LEUKOCYTE INFILTRATES
A. Early (neutrophilic)
infiltrates and
congested blood
vessels
B. Later (mononuclear)
cellular infiltrates
SEROUS INFLAMMATION
serous effusion
FIBRINOUS PERICARDITIS
deposits of fibrin fibrin exudate
pericardial surface
PURULENT INFLAMMATION
bacterial abscesses abscess contains neutrophils and cellular debris; surrounded by
congested blood vessels
bacterial abscesses
bacterial abscesses
DUODENAL ULCER
chronic duodenal ulcer
duodenal ulcer crater w/ acute inflammatory exudate in the base
ACUTE INFLAMMATION (lung)
CHRONIC INFLAMMATION (lung) acute bronchopneumonia
destruction of parenchyma; normal alveoli replaced by
spaces lined by cuboidal epithelium
chronic
inflammatory cells
fibrosis
neutrophils fill the alveolar spaces
TUBERCULOUS GRANULOMA
- central necrosis +
multiple Langhans-
type giant cell +
epithelioid cells +
lymphocytes
VENOUS LEG ULCER | ARTERIAL ULCER | DIABETIC ULCER | PRESSURE SORE
CHRONIC INFLAMMATION AND
ULCER CRATER GRANULATION TISSUE
HYPERTROPHIC SCAR | KELOID | KELOID DIN PERO MICROSCOPIC
LIVER WITH CHRONIC PASSIVE CONGESTION
AND HEMORRHAGIC NECROSIS
NUTMEG LIVER PATTERN CENTRILOBULAR NECROSIS
THROMBOCYTOPENIA
Punctate petechial hemorrhages of
FATAL INTRACEREBRAL
the colonic mucosa BLEED
MURAL THROMBI
laminated
thrombus
thrombus
LPO; THROMBOSED ARTERY
original lumen is delineated by the
internal elastic lamina
DVT THROMBUS
BONE MARROW EMBOLUS IN PULMONARY
CIRCULATION
hematopoietic
cells
early organizing
thrombus
marrow fat
AMNIOTIC FLUID EMBOLISM
MYOCARDIAL INFARCTION
URIC ACID: GOUT, OLECRANON BURSA
*most common joint affected in gout: metatarsopharyngeal joint
*PPT NI DOC
URIC ACID: GOUT, OLECRANON BURSA
inflammatory cells surrounding
area of monosodium the monosodium urate
urate
*PPT NI DOC
CHOLESTEROL;
Atheroma,
Aorta
*PPT NI DOC
CHOLESTEROL;
Atheroma,
Aorta
*PPT NI DOC
PIGMENT ACCUMULATION:
Hemosiderin-laden Macrophages in CPC; lungs
*CPC is consequence of left-sided hf
*PPT NI DOC
CALCIUM DEPOSIT:
Monckeberg’s Sclerosis
(Medial Calcinosis /
Medial Calcific
Arteriosclerosis), Uterus
*calcification w/in tunica media
*PPT NI DOC
INFLAMMATORY CELLS
*PPT NI DOC
ACUTE INFLAMMATION:
Acute Appendecitis
*PPT NI DOC
ACUTE INFLAMMATION:
Acute Appendecitis
*PPT NI DOC
ACUTE INFLAMMATION:
Acute Pyelonephritis
*PPT NI DOC
CHRONIC INFLAMMATION:
Chronic Pyelonephritis
*PPT NI DOC
CHRONIC INFLAMMATION:
Chronic Cholecystitis, Gallbladder
*PPT NI DOC
CHRONIC GRANULOMATOUS INFLAMMATION:
Tuberculosis, Intestine
*PPT NI DOC
CHRONIC GRANULOMATOUS
INFLAMMATION: TB of Lung
- diagnostic cell of
TB granuloma:
epitheloid cells
- epitheloid =
activated
Langhan’s Giant Cells;
horseshoe shape macrophages
- Langhan’s giant
cells = fusion of
activated
macrophages
(thru IFN-y)
*PPT NI DOC
REPAIR: Liver Cirrhosis
*PPT NI DOC
CHRONIC CERVICITIS WITH METAPLASIA
Small round dark lymphocytes are seen in the
submucosa + hemorrhage
*GOOGLE
BARRETT ESOPHAGEUS; Dysplasia
columnar
squamous
*GOOGLE
ENDOMETRIAL HYPERPLASIA
*GOOGLE
BPH; prostate
*GOOGLE
TATTOO PIGMENT
