SAFETY DATA SHEET
Creation Date 28-Apr-2009 Revision Date 19-Jan-2018 Revision Number 6
1. Identification
Product Name Acetone
Cat No. : AC177170000; AC177170010; AC177170025; AC177170050;
AC177170100; AC177170250
CAS-No 67-64-1
Synonyms 2-Propanone
Recommended Use Laboratory chemicals.
Uses advised against Not for food, drug, pesticide or biocidal product use
Details of the supplier of the safety data sheet
Company
Fisher Scientific Acros Organics
One Reagent Lane One Reagent Lane
Fair Lawn, NJ 07410 Fair Lawn, NJ 07410
Tel: (201) 796-7100
Emergency Telephone Number
For information US call: 001-800-ACROS-01 / Europe call: +32 14 57 52 11
Emergency Number US:001-201-796-7100 / Europe: +32 14 57 52 99
CHEMTREC Tel. No.US:001-800-424-9300 / Europe:001-703-527-3887
2. Hazard(s) identification
Classification
This chemical is considered hazardous by the 2012 OSHA Hazard Communication Standard (29 CFR 1910.1200)
Flammable liquids Category 2
Serious Eye Damage/Eye Irritation Category 2
Specific target organ toxicity (single exposure) Category 3
Target Organs - Central nervous system (CNS).
Specific target organ toxicity - (repeated exposure) Category 2
Target Organs - Kidney, Liver, spleen, Blood.
Label Elements
Signal Word
Danger
Hazard Statements
Highly flammable liquid and vapor
Causes serious eye irritation
May cause drowsiness or dizziness
May cause damage to organs through prolonged or repeated exposure
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Precautionary Statements
Prevention
Wash face, hands and any exposed skin thoroughly after handling
Do not breathe dust/fume/gas/mist/vapors/spray
Use only outdoors or in a well-ventilated area
Keep away from heat/sparks/open flames/hot surfaces. - No smoking
Keep container tightly closed
Ground/bond container and receiving equipment
Use explosion-proof electrical/ventilating/lighting/equipment
Use only non-sparking tools
Take precautionary measures against static discharge
Wear protective gloves/protective clothing/eye protection/face protection
Keep cool
Response
Get medical attention/advice if you feel unwell
Inhalation
IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing
Call a POISON CENTER or doctor/physician if you feel unwell
Skin
IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water/shower
Eyes
IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing
If eye irritation persists: Get medical advice/attention
Fire
In case of fire: Use CO2, dry chemical, or foam for extinction
Storage
Store in a well-ventilated place. Keep container tightly closed
Store locked up
Disposal
Dispose of contents/container to an approved waste disposal plant
Hazards not otherwise classified (HNOC)
Repeated exposure may cause skin dryness or cracking
3. Composition/Information on Ingredients
Component CAS-No Weight %
Acetone 67-64-1 >95
4. First-aid measures
General Advice If symptoms persist, call a physician.
Eye Contact Rinse immediately with plenty of water, also under the eyelids, for at least 15 minutes. Get
medical attention.
Skin Contact Wash off immediately with plenty of water for at least 15 minutes. If skin irritation persists,
call a physician.
Inhalation Move to fresh air. If not breathing, give artificial respiration. Get medical attention if
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symptoms occur.
Ingestion Clean mouth with water and drink afterwards plenty of water.
Most important symptoms and None reasonably foreseeable. Symptoms of overexposure may be headache, dizziness,
effects tiredness, nausea and vomiting: May cause pulmonary edema: Inhalation of high vapor
concentrations may cause symptoms like headache, dizziness, tiredness, nausea and
vomiting
Notes to Physician Treat symptomatically
5. Fire-fighting measures
Suitable Extinguishing Media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Cool closed
containers exposed to fire with water spray.
Unsuitable Extinguishing Media Water may be ineffective
Flash Point -20 °C / -4 °F
Method - Closed cup
Autoignition Temperature 465 °C / 869 °F
Explosion Limits
Upper 12.8 vol %
Lower 2.5 vol %
Oxidizing Properties Not oxidising
Sensitivity to Mechanical Impact No information available
Sensitivity to Static Discharge No information available
Specific Hazards Arising from the Chemical
Flammable. Risk of ignition. Containers may explode when heated. Vapors may form explosive mixtures with air. Vapors may
travel to source of ignition and flash back.
Hazardous Combustion Products
Carbon monoxide (CO) Carbon dioxide (CO2) Formaldehyde Methanol
Protective Equipment and Precautions for Firefighters
As in any fire, wear self-contained breathing apparatus pressure-demand, MSHA/NIOSH (approved or equivalent) and full
protective gear.
NFPA
Health Flammability Instability Physical hazards
2 3 0 N/A
6. Accidental release measures
Personal Precautions Use personal protective equipment. Ensure adequate ventilation. Remove all sources of
ignition. Take precautionary measures against static discharges.
Environmental Precautions Should not be released into the environment.
Methods for Containment and Clean Soak up with inert absorbent material. Keep in suitable, closed containers for disposal.
Up Remove all sources of ignition. Use spark-proof tools and explosion-proof equipment.
7. Handling and storage
Handling Do not get in eyes, on skin, or on clothing. Wear personal protective equipment. Ensure
adequate ventilation. Avoid ingestion and inhalation. Keep away from open flames, hot
surfaces and sources of ignition. Use only non-sparking tools. To avoid ignition of vapors by
static electricity discharge, all metal parts of the equipment must be grounded. Take
precautionary measures against static discharges.
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Storage Flammables area. Keep containers tightly closed in a dry, cool and well-ventilated place.
Keep away from heat and sources of ignition.
8. Exposure controls / personal protection
Exposure Guidelines
Component ACGIH TLV OSHA PEL NIOSH IDLH Mexico OEL (TWA)
Acetone TWA: 250 ppm (Vacated) TWA: 750 ppm IDLH: 2500 ppm TWA: 1000 ppm
STEL: 500 ppm (Vacated) TWA: 1800 mg/m3 TWA: 250 ppm TWA: 2400 mg/m3
(Vacated) STEL: 2400 TWA: 590 mg/m3 STEL: 1260 ppm
mg/m3 STEL: 3000 mg/m3
(Vacated) STEL: 1000 ppm
TWA: 1000 ppm
TWA: 2400 mg/m3
Legend
ACGIH - American Conference of Governmental Industrial Hygienists
OSHA - Occupational Safety and Health Administration
NIOSH IDLH: The National Institute for Occupational Safety and Health Immediately Dangerous to Life or Health
Engineering Measures Ensure adequate ventilation, especially in confined areas. Ensure that eyewash stations
and safety showers are close to the workstation location. Use explosion-proof
electrical/ventilating/lighting/equipment.
Personal Protective Equipment
Eye/face Protection Wear appropriate protective eyeglasses or chemical safety goggles as described by
OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard
EN166.
Skin and body protection Long sleeved clothing.
Respiratory Protection Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard
EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if
exposure limits are exceeded or if irritation or other symptoms are experienced.
Hygiene Measures Handle in accordance with good industrial hygiene and safety practice.
9. Physical and chemical properties
Physical State Liquid
Appearance Colorless
Odor sweet
Odor Threshold 19.8 ppm
pH 7
Melting Point/Range -95 °C / -139 °F
Boiling Point/Range 56 °C / 132.8 °F
Flash Point -20 °C / -4 °F
Method - Closed cup
Evaporation Rate 5.6 (Butyl Acetate = 1.0)
Flammability (solid,gas) Not applicable
Flammability or explosive limits
Upper 12.8 vol %
Lower 2.5 vol %
Vapor Pressure 247 mbar @ 20 °C
Vapor Density 2.0
Specific Gravity 0.790
Solubility Soluble in water
Partition coefficient; n-octanol/water No data available
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Autoignition Temperature 465 °C / 869 °F
Decomposition Temperature > 4°C
Viscosity 0.32 mPa.s @ 20 °C
Molecular Formula C3 H6 O
Molecular Weight 58.08
Refractive index 1.358 - 1.359
10. Stability and reactivity
Reactive Hazard None known, based on information available
Stability Stable under normal conditions.
Conditions to Avoid Heat, flames and sparks. Incompatible products. Keep away from open flames, hot
surfaces and sources of ignition.
Incompatible Materials Strong oxidizing agents, Strong reducing agents, Strong bases, Peroxides, Halogenated
compounds, Alkali metals, Amines
Hazardous Decomposition Products Carbon monoxide (CO), Carbon dioxide (CO2), Formaldehyde, Methanol
Hazardous Polymerization Hazardous polymerization does not occur.
Hazardous Reactions None under normal processing.
11. Toxicological information
Acute Toxicity
Product Information
Component Information
Component LD50 Oral LD50 Dermal LC50 Inhalation
Acetone 5800 mg/kg ( Rat ) > 15800 mg/kg (rabbit) 76 mg/l, 4 h, (rat)
> 7400 mg/kg (rat)
Toxicologically Synergistic Carbon tetrachloride; Chloroform; Trichloroethylene; Bromodichloromethane;
Products Dibromochloromethane; N-nitrosodimethylamine; 1,1,2-Trichloroethane; Styrene;
Acetonitrile, 2,5-Hexanedione; Ethanol; 1,2-Dichlorobenzene
Delayed and immediate effects as well as chronic effects from short and long-term exposure
Irritation Irritating to eyes and skin
Sensitization No information available
Carcinogenicity The table below indicates whether each agency has listed any ingredient as a carcinogen.
Component CAS-No IARC NTP ACGIH OSHA Mexico
Acetone 67-64-1 Not listed Not listed Not listed Not listed Not listed
Mutagenic Effects No information available
Reproductive Effects No information available.
Developmental Effects No information available.
Teratogenicity No information available.
STOT - single exposure Central nervous system (CNS)
STOT - repeated exposure Kidney Liver spleen Blood
Aspiration hazard No information available
Symptoms / effects,both acute and Symptoms of overexposure may be headache, dizziness, tiredness, nausea and vomiting:
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delayed May cause pulmonary edema: Inhalation of high vapor concentrations may cause
symptoms like headache, dizziness, tiredness, nausea and vomiting
Endocrine Disruptor Information No information available
Other Adverse Effects The toxicological properties have not been fully investigated.
12. Ecological information
Ecotoxicity
.
Component Freshwater Algae Freshwater Fish Microtox Water Flea
Acetone NOEC = 430 mg/l (algae; 96 Oncorhynchus mykiss: LC50 EC50 = 14500 mg/L/15 min EC50 = 8800 mg/L/48h
h) = 5540 mg/l 96h EC50 = 12700 mg/L/48h
Alburnus alburnus: LC50 = EC50 = 12600 mg/L/48h
11000 mg/l 96h
Leuciscus idus: LC50 =
11300 mg/L/48h
Salmo gairdneri: LC50 =
6100 mg/L/24h
Persistence and Degradability Persistence is unlikely based on information available.
Bioaccumulation/ Accumulation No information available.
Mobility Will likely be mobile in the environment due to its volatility.
Component log Pow
Acetone -0.24
13. Disposal considerations
Waste Disposal Methods Chemical waste generators must determine whether a discarded chemical is classified as a
hazardous waste. Chemical waste generators must also consult local, regional, and
national hazardous waste regulations to ensure complete and accurate classification.
Component RCRA - U Series Wastes RCRA - P Series Wastes
Acetone - 67-64-1 U002 -
14. Transport information
DOT
UN-No UN1090
Proper Shipping Name ACETONE
Hazard Class 3
Packing Group II
TDG
UN-No UN1090
Proper Shipping Name ACETONE
Hazard Class 3
Packing Group II
IATA
UN-No UN1090
Proper Shipping Name ACETONE
Hazard Class 3
Packing Group II
IMDG/IMO
UN-No UN1090
Proper Shipping Name ACETONE
Hazard Class 3
Packing Group II
15. Regulatory information
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All of the components in the product are on the following Inventory lists: X = listed
International Inventories
Component TSCA DSL NDSL EINECS ELINCS NLP PICCS ENCS AICS IECSC KECL
Acetone X X - 200-662-2 - X X X X X
Legend:
X - Listed
E - Indicates a substance that is the subject of a Section 5(e) Consent order under TSCA.
F - Indicates a substance that is the subject of a Section 5(f) Rule under TSCA.
N - Indicates a polymeric substance containing no free-radical initiator in its inventory name but is considered to cover the designated
polymer made with any free-radical initiator regardless of the amount used.
P - Indicates a commenced PMN substance
R - Indicates a substance that is the subject of a Section 6 risk management rule under TSCA.
S - Indicates a substance that is identified in a proposed or final Significant New Use Rule
T - Indicates a substance that is the subject of a Section 4 test rule under TSCA.
XU - Indicates a substance exempt from reporting under the Inventory Update Rule, i.e. Partial Updating of the TSCA Inventory Data Base
Production and Site Reports (40 CFR 710(B).
Y1 - Indicates an exempt polymer that has a number-average molecular weight of 1,000 or greater.
Y2 - Indicates an exempt polymer that is a polyester and is made only from reactants included in a specified list of low concern reactants
that comprises one of the eligibility criteria for the exemption rule.
U.S. Federal Regulations
TSCA 12(b) Not applicable
SARA 313 Not applicable
SARA 311/312 Hazard Categories See section 2 for more information
CWA (Clean Water Act) Not applicable
Clean Air Act Not applicable
OSHA Occupational Safety and Health Administration
Not applicable
CERCLA This material, as supplied, contains one or more substances regulated as a hazardous
substance under the Comprehensive Environmental Response Compensation and Liability
Act (CERCLA) (40 CFR 302)
Component Hazardous Substances RQs CERCLA EHS RQs
Acetone 5000 lb -
California Proposition 65 This product does not contain any Proposition 65 chemicals
U.S. State Right-to-Know
Regulations
Component Massachusetts New Jersey Pennsylvania Illinois Rhode Island
Acetone X X X - X
U.S. Department of Transportation
Reportable Quantity (RQ): Y
DOT Marine Pollutant N
DOT Severe Marine Pollutant N
U.S. Department of Homeland Security
This product contains the following DHS chemicals:
Component DHS Chemical Facility Anti-Terrorism Standard
Acetone 2000 lb STQ
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Other International Regulations
Mexico - Grade Serious risk, Grade 3
16. Other information
Prepared By Regulatory Affairs
Thermo Fisher Scientific
Email: EMSDS.RA@thermofisher.com
Creation Date 28-Apr-2009
Revision Date 19-Jan-2018
Print Date 19-Jan-2018
Revision Summary This document has been updated to comply with the US OSHA HazCom 2012 Standard
replacing the current legislation under 29 CFR 1910.1200 to align with the Globally
Harmonized System of Classification and Labeling of Chemicals (GHS).
Disclaimer
The information provided in this Safety Data Sheet is correct to the best of our knowledge, information and belief at the
date of its publication. The information given is designed only as a guidance for safe handling, use, processing, storage,
transportation, disposal and release and is not to be considered a warranty or quality specification. The information
relates only to the specific material designated and may not be valid for such material used in combination with any other
materials or in any process, unless specified in the text
End of SDS
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