SAFETY DATA SHEET
Creation Date 13-Oct-2009 Revision Date 25-Dec-2021 Revision Number 6
1. Identification
Product Name Ethyl acetate
Cat No. : AC326900000; AC326900010; AC326900025; AC326901000;
AC326902500; AC326905000
CAS No 141-78-6
Synonyms Acetic acid ethyl ester
Recommended Use Laboratory chemicals.
Uses advised against Food, drug, pesticide or biocidal product use.
Details of the supplier of the safety data sheet
Company
Fisher Scientific Company Acros Organics
One Reagent Lane One Reagent Lane
Fair Lawn, NJ 07410 Fair Lawn, NJ 07410
Tel: (201) 796-7100
Emergency Telephone Number For information US call: 001-800-ACROS-01 / Europe call: +32 14 57 52 11
Emergency Number US:001-201-796-7100 / Europe: +32 14 57 52 99
CHEMTREC Tel. No.US:001-800-424-9300 / Europe:001-703-527-3887
2. Hazard(s) identification
Classification
This chemical is considered hazardous by the 2012 OSHA Hazard Communication Standard (29 CFR 1910.1200)
Flammable liquids Category 2
Serious Eye Damage/Eye Irritation Category 2
Specific target organ toxicity (single exposure) Category 3
Target Organs - Central nervous system (CNS).
Label Elements
Signal Word
Danger
Hazard Statements
Highly flammable liquid and vapor
Causes serious eye irritation
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May cause drowsiness or dizziness
Precautionary Statements
Prevention
Wash face, hands and any exposed skin thoroughly after handling
Do not breathe dust/fume/gas/mist/vapors/spray
Use only outdoors or in a well-ventilated area
Keep away from heat/sparks/open flames/hot surfaces. - No smoking
Keep container tightly closed
Ground/bond container and receiving equipment
Use explosion-proof electrical/ventilating/lighting equipment
Use only non-sparking tools
Take precautionary measures against static discharge
Wear protective gloves/protective clothing/eye protection/face protection
Keep cool
Response
Get medical attention/advice if you feel unwell
Inhalation
IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing
Call a POISON CENTER or doctor/physician if you feel unwell
Skin
IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water/shower
Eyes
IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing
If eye irritation persists: Get medical advice/attention
Fire
In case of fire: Use CO2, dry chemical, or foam for extinction
Storage
Store in a well-ventilated place. Keep container tightly closed
Store locked up
Disposal
Dispose of contents/container to an approved waste disposal plant
Hazards not otherwise classified (HNOC)
Repeated exposure may cause skin dryness or cracking
3. Composition/Information on Ingredients
Component CAS No Weight %
Ethyl acetate 141-78-6 >95
4. First-aid measures
General Advice If symptoms persist, call a physician.
Eye Contact Rinse immediately with plenty of water, also under the eyelids, for at least 15 minutes. Get
medical attention.
Skin Contact Wash off immediately with plenty of water for at least 15 minutes. If skin irritation persists,
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call a physician.
Inhalation Remove to fresh air. If not breathing, give artificial respiration. Get medical attention if
symptoms occur.
Ingestion Clean mouth with water and drink afterwards plenty of water.
Most important symptoms and Difficulty in breathing. May cause central nervous system depression: Inhalation of high
effects vapor concentrations may cause symptoms like headache, dizziness, tiredness, nausea
and vomiting
Notes to Physician Treat symptomatically
5. Fire-fighting measures
Suitable Extinguishing Media Water spray, carbon dioxide (CO2), dry chemical, alcohol-resistant foam.
Unsuitable Extinguishing Media Water may be ineffective, Do not use a solid water stream as it may scatter and spread fire
Flash Point -4 °C / 24.8 °F
Method - CC (closed cup)
Autoignition Temperature 427 °C / 800.6 °F
Explosion Limits
Upper 11.5 vol %
Lower 2.0 vol %
Oxidizing Properties Not oxidising
Sensitivity to Mechanical Impact No information available
Sensitivity to Static Discharge No information available
Specific Hazards Arising from the Chemical
Flammable. Risk of ignition. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back.
Containers may explode when heated.
Hazardous Combustion Products
Carbon monoxide (CO). Carbon dioxide (CO2).
Protective Equipment and Precautions for Firefighters
As in any fire, wear self-contained breathing apparatus pressure-demand, MSHA/NIOSH (approved or equivalent) and full
protective gear.
NFPA
Health Flammability Instability Physical hazards
2 3 0 N/A
6. Accidental release measures
Personal Precautions Use personal protective equipment as required. Ensure adequate ventilation.
Environmental Precautions Should not be released into the environment. See Section 12 for additional Ecological
Information.
Methods for Containment and Clean Soak up with inert absorbent material. Keep in suitable, closed containers for disposal.
Up
7. Handling and storage
Handling Ensure adequate ventilation. Wear personal protective equipment/face protection. Do not
get in eyes, on skin, or on clothing. Avoid ingestion and inhalation.
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Storage. Flammables area. Keep away from heat, sparks and flame. Keep container tightly closed in
a dry and well-ventilated place. Incompatible Materials. Strong oxidizing agents. Strong
acids. Amines. Peroxides.
8. Exposure controls / personal protection
Exposure Guidelines
Component ACGIH TLV OSHA PEL NIOSH IDLH Mexico OEL (TWA)
Ethyl acetate TWA: 400 ppm (Vacated) TWA: 400 ppm IDLH: 2000 ppm TWA: 400 ppm
(Vacated) TWA: 1400 mg/m3 TWA: 400 ppm
TWA: 400 ppm TWA: 1400 mg/m3
TWA: 1400 mg/m3
Legend
ACGIH - American Conference of Governmental Industrial Hygienists
OSHA - Occupational Safety and Health Administration
NIOSH IDLH: NIOSH - National Institute for Occupational Safety and Health
Engineering Measures Ensure adequate ventilation, especially in confined areas. Use explosion-proof
electrical/ventilating/lighting equipment. Ensure that eyewash stations and safety showers
are close to the workstation location.
Personal Protective Equipment
Eye/face Protection Wear appropriate protective eyeglasses or chemical safety goggles as described by
OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard
EN166.
Skin and body protection Wear appropriate protective gloves and clothing to prevent skin exposure.
Respiratory Protection No protective equipment is needed under normal use conditions.
Hygiene Measures Handle in accordance with good industrial hygiene and safety practice.
9. Physical and chemical properties
Physical State Liquid
Appearance Colorless
Odor sweet
Odor Threshold 50 ppm
pH No information available
Melting Point/Range -83.5 °C / -118.3 °F
Boiling Point/Range 75 - 78 °C / 167 - 172.4 °F
Flash Point -4 °C / 24.8 °F
Method - CC (closed cup)
Evaporation Rate 6.2
Flammability (solid,gas) Not applicable
Flammability or explosive limits
Upper 11.5 vol %
Lower 2.0 vol %
Vapor Pressure 103 mbar @ 20°C
Vapor Density 3.04
Specific Gravity 0.902
Solubility Slightly soluble in water
Partition coefficient; n-octanol/water No data available
Autoignition Temperature 427 °C / 800.6 °F
Decomposition Temperature No information available
Viscosity 0.45 cP @ 20 °C
Molecular Formula C4 H8 O2
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Molecular Weight 88.11
Surface tension 24 mN/m @ 20°C
10. Stability and reactivity
Reactive Hazard None known, based on information available
Stability Stable under normal conditions.
Conditions to Avoid Incompatible products. Keep away from open flames, hot surfaces and sources of ignition.
Incompatible Materials Strong oxidizing agents, Strong acids, Amines, Peroxides
Hazardous Decomposition Products Carbon monoxide (CO), Carbon dioxide (CO2)
Hazardous Polymerization Hazardous polymerization does not occur.
Hazardous Reactions None under normal processing.
11. Toxicological information
Acute Toxicity
Product Information
Component Information
Component LD50 Oral LD50 Dermal LC50 Inhalation
Ethyl acetate 10,200 mg/kg ( Rat ) > 20 mL/kg ( Rabbit ) 58 mg/l (rat; 8 h)
> 18000 mg/kg ( Rabbit )
Toxicologically Synergistic No information available
Products
Delayed and immediate effects as well as chronic effects from short and long-term exposure
Irritation Irritating to eyes
Sensitization No information available
Carcinogenicity The table below indicates whether each agency has listed any ingredient as a carcinogen.
Component CAS No IARC NTP ACGIH OSHA Mexico
Ethyl acetate 141-78-6 Not listed Not listed Not listed Not listed Not listed
Mutagenic Effects No information available
Reproductive Effects No information available.
Developmental Effects No information available.
Teratogenicity No information available.
STOT - single exposure Central nervous system (CNS)
STOT - repeated exposure None known
Aspiration hazard No information available
Symptoms / effects,both acute and May cause central nervous system depression: Inhalation of high vapor concentrations may
delayed cause symptoms like headache, dizziness, tiredness, nausea and vomiting
Endocrine Disruptor Information No information available
Other Adverse Effects The toxicological properties have not been fully investigated.
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12. Ecological information
Ecotoxicity
Do not empty into drains.
Component Freshwater Algae Freshwater Fish Microtox Water Flea
Ethyl acetate EC50 = 3300 mg/L/48h Fathead minnow: LC50: 230 EC50 = 1180 mg/L 5 min EC50 = 717 mg/L/48h
mg/l/ 96h EC50 = 1500 mg/L 15 min
Gold orfe: LC50: 270 EC50 = 5870 mg/L 15 min
mg/L/48h EC50 = 7400 mg/L 2 h
Persistence and Degradability Persistence is unlikely based on information available.
Bioaccumulation/ Accumulation No information available.
Mobility Will likely be mobile in the environment due to its volatility.
Component log Pow
Ethyl acetate 0.6
13. Disposal considerations
Waste Disposal Methods Chemical waste generators must determine whether a discarded chemical is classified as a
hazardous waste. Chemical waste generators must also consult local, regional, and
national hazardous waste regulations to ensure complete and accurate classification.
Component RCRA - U Series Wastes RCRA - P Series Wastes
Ethyl acetate - 141-78-6 U112 -
14. Transport information
DOT
UN-No UN1173
Proper Shipping Name ETHYL ACETATE
Hazard Class 3
Packing Group II
TDG
UN-No UN1173
Proper Shipping Name ETHYL ACETATE
Hazard Class 3
Packing Group II
IATA
UN-No UN1173
Proper Shipping Name ETHYL ACETATE
Hazard Class 3
Packing Group II
IMDG/IMO
UN-No UN1173
Proper Shipping Name ETHYL ACETATE
Hazard Class 3
Packing Group II
15. Regulatory information
United States of America Inventory
Component CAS No TSCA TSCA Inventory notification - TSCA - EPA Regulatory
Active-Inactive Flags
Ethyl acetate 141-78-6 X ACTIVE -
Legend:
TSCA US EPA (TSCA) - Toxic Substances Control Act, (40 CFR Part 710)
X - Listed
'-' - Not Listed
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TSCA 12(b) - Notices of Export Not applicable
International Inventories
Canada (DSL/NDSL), Europe (EINECS/ELINCS/NLP), Philippines (PICCS), Japan (ENCS), Japan (ISHL), Australia (AICS), China (IECSC), Korea
(KECL).
Component CAS No DSL NDSL EINECS PICCS ENCS ISHL AICS IECSC KECL
Ethyl acetate 141-78-6 X - 205-500-4 X X X X X KE-00047
KECL - NIER number or KE number (http://ncis.nier.go.kr/en/main.do)
U.S. Federal Regulations
SARA 313 Not applicable
SARA 311/312 Hazard Categories See section 2 for more information
CWA (Clean Water Act) Not applicable
Clean Air Act Not applicable
OSHA - Occupational Safety and Not applicable
Health Administration
CERCLA This material, as supplied, contains one or more substances regulated as a hazardous
substance under the Comprehensive Environmental Response Compensation and Liability
Act (CERCLA) (40 CFR 302)
Component Hazardous Substances RQs CERCLA EHS RQs
Ethyl acetate 5000 lb -
California Proposition 65 This product does not contain any Proposition 65 chemicals.
U.S. State Right-to-Know
Regulations
Component Massachusetts New Jersey Pennsylvania Illinois Rhode Island
Ethyl acetate X X X - X
U.S. Department of Transportation
Reportable Quantity (RQ): Y
DOT Marine Pollutant N
DOT Severe Marine Pollutant N
U.S. Department of Homeland This product does not contain any DHS chemicals.
Security
Other International Regulations
Mexico - Grade Serious risk, Grade 3
Authorisation/Restrictions according to EU REACH
Component REACH (1907/2006) - Annex XIV - REACH (1907/2006) - Annex XVII - REACH Regulation (EC
Substances Subject to Restrictions on Certain Dangerous 1907/2006) article 59 - Candidate
Authorization Substances List of Substances of Very High
Concern (SVHC)
Ethyl acetate - Use restricted. See item 75. -
(see link for restriction details)
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https://echa.europa.eu/substances-restricted-under-reach
Safety, health and environmental regulations/legislation specific for the substance or mixture
Component CAS No OECD HPV Persistent Organic Ozone Depletion Restriction of
Pollutant Potential Hazardous
Substances (RoHS)
Ethyl acetate 141-78-6 Listed Not applicable Not applicable Not applicable
Component CAS No Seveso III Directive Seveso III Directive Rotterdam Basel Convention
(2012/18/EC) - (2012/18/EC) - Convention (PIC) (Hazardous Waste)
Qualifying Quantities Qualifying Quantities
for Major Accident for Safety Report
Notification Requirements
Ethyl acetate 141-78-6 Not applicable Not applicable Not applicable Annex I - Y42
16. Other information
Prepared By Regulatory Affairs
Thermo Fisher Scientific
Email: EMSDS.RA@thermofisher.com
Creation Date 13-Oct-2009
Revision Date 25-Dec-2021
Print Date 25-Dec-2021
Revision Summary This document has been updated to comply with the US OSHA HazCom 2012 Standard
replacing the current legislation under 29 CFR 1910.1200 to align with the Globally
Harmonized System of Classification and Labeling of Chemicals (GHS).
Disclaimer
The information provided in this Safety Data Sheet is correct to the best of our knowledge, information and belief at the
date of its publication. The information given is designed only as a guidance for safe handling, use, processing, storage,
transportation, disposal and release and is not to be considered a warranty or quality specification. The information
relates only to the specific material designated and may not be valid for such material used in combination with any other
materials or in any process, unless specified in the text
End of SDS
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