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Bab Iv Formulasi Dan Perhitungan

This document contains formulations and calculations for a cough syrup. It provides two main formulations, one using sorbitol as a sweetener and the other using saccharin. It then shows sample calculations for determining the daily dosage and amount of each ingredient needed per 60ml of syrup. Lastly, it includes calculations to determine the amount of citric acid and sodium citrate needed as buffers to achieve a pH of 4 for the finished syrup formulation.

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Putri Febriani
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38 views5 pages

Bab Iv Formulasi Dan Perhitungan

This document contains formulations and calculations for a cough syrup. It provides two main formulations, one using sorbitol as a sweetener and the other using saccharin. It then shows sample calculations for determining the daily dosage and amount of each ingredient needed per 60ml of syrup. Lastly, it includes calculations to determine the amount of citric acid and sodium citrate needed as buffers to achieve a pH of 4 for the finished syrup formulation.

Uploaded by

Putri Febriani
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as DOCX, PDF, TXT or read online on Scribd
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BAB IV

FORMULASI dan PERHITUNGAN

1. Formulasi
a) Formula Utama
R/ Bromhexine 8 mg (Zat aktif)
Sorbitol 25% (Pemanis)
Natrium Benzoat 0,1% (Pengawet)
Etanol 8% (Pelarut)
Menthol 0,01% (Perasa)
Asam Sitrat 0.185 gram (Dapar)
Natrium Sitrat 0,015 gram (Dapar)
Aquadest ad 60 ml
b) Formula Alternatif
R/ Bromhexine 8 mg (Zat aktif)
Sakarin 0,1% (Pemanis)
Methil Paraben 0,1% (Pengawet)
Etanol 8% (Pelarut)
Menthol 0,01% (Perasa)
Aquadest ad 60 ml

2. Perhitungan
a) Perhitungan Dosis
Bromhexine (8 mg/16 ml) Untuk dewasa 17 tahun
17
1 X pakai = x 8 mg = 5,6 mg
24
1 hari pakai = 2 x 5,6 mg = 12,2 mg
b) Perhitungan Bahan
1. Bromhexine 8 mg 0,16%
8 mg
x 60 ml = 96 mg 0,096 gram
5 ml
2. Etanol 8%
8
x 60 ml = 4,8 ml
100
3. Sorbitol 25%
25
x 60 ml = 15 ml
100
4. Natrium Benzoat 0,1%
0,1
x 60 ml = 0,06 ml
100
5. Menthol 0,1%
0,1
x 60 ml = 0,06 ml
100
6. Aquadest 60 ml
60 ml – (0,096+15+4,8+0,06+0,06) = 60 ml – 19,962
= 40,038 ml
c) Perhitungan Dapar
Bromhexine = 60 ml
pH sediaan = 4
pH dapar Asam Sitrat = 2-8
Pka1 = 3,15
Pka2 = 4,77
Pka3 = 6,40

Pka1 = ̄ log ka
3,15 = ̄ log ka
Ka = antilog 3,15
Ka = 14 x 10²
pH = ̄ log (H⁺)
8 = ̄ log (H⁺)
(H⁺) = antilog – 8 = 1 x 10⁸

Kapasitas Dapar
β = 2,303 x C x Ka ¿¿
( 14 x 102 ) x (1 x 108 )
0,01 = 2.303 x C x
{( 14 x 102 ) +(1 x 108 ) }²
14 x 10 8 ⁰
0,01 = 2.303 x C x
(10.000 x 1.400) ²
8
0,01 = 2,303 x C x 14 x 10 ⁰
¿¿
14 x 10 ⁸⁰
0,01 = 2,303 x C x
196 x 102
0,01 = 2,303 x C x 0,07 x 10‾²
0,01 0,01
C = =
2,303 x 0,07 x 10 ‾ ² 2,303 x 7 x 10 ‾ ⁴
0,01
C = = 0,0016121 = 0,002
1,621 x 10 ‾ ²

g
pH = Pka + log
a
g
8 = 3,15 + log
a
g
Log = 8 – 3,15
a
g
Log = 4,8
a
g
= antilog 4,8
a
g
= 63096,7
a
a = 630976,7 (a)

C = (g) + (a)
C = 0,001
0,001 = 63096,7 (g) + (a)
0,001 = 63096,7
0,001
(a) = Log
63096,7
(a) = 1,58 x 10‾⁸
C = (g) – (a)
0,001 = (g) + 1,58 + 10‾⁸ = 9,9 x 10‾⁴

M. Asam = BM x 1,58 x 10‾⁸ x 0,006


= 192,124 x 1,58 x 10‾⁸ x 0,06
= 18,2 x 10‾⁸ 0,000182 = 0,182
M. Garam = BM x garam x volume
= 258,07 x 9,9 x 10‾⁸ x 0,06
= 0,015 gram

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