1. Which of the following best defines the gross appearance of organ showing amyloid deposition?
a. Flea bitten
b. Granular
c. Waxy
d. Nodular
2. Amyloid deposits stain positively with all of the following except:
a) Congo-red
b) Crystal violet
c) Methenamine silver
d) Thioflavin T
3. All are correct about Amyloid EXCEPT:
a. occurs in chronic inflammatory disorders
b. occurs in medullary carcinoma of the thyroid
c. is a basophilic substance which can be stained with
Congo red
d. weakens the walls of blood vessels
e. causes renal failure
4. The gingival biopsy is used for diagnosis of:
a. Scurvy
b. sarcoidosis
c. Amyloidosis
d. SLE
5. True about senile systemic amyloidosis:
a. Systemic involvement present
b. Β amyloid
c. AA amyloid
d. Heart failure is the predominant presentation
e. Transthyretin
6. Major fibril protein in Primary Amyloidosis is?
a. AL
b. AA
c. Transthyretin
d. Procalcitonin
7. Congo-red with amyloid produces:
a. Dark brown color
b. Blue color
c. Brilliant pink color
d. Khaki color
8. Bone marrow in AL amyloidosis shows:
a. Bone marrow plasmacytosis
b. Granulomatous reaction
c. Fibrosis
d. Giant cell formation
9. Which of the following amyloid forms is seen in secondary amyloidosis associated with chronic
disease:
a. Amyloid Associated Protein
b. Amyloid light chain
c. Beta 2 amyloid
d. ATTR
10. Senile cardiac amyloidosis associated protein is:
a. Transthyretin
b. AANF
c. Beta 2 microglobulin
d. AL
11. Amyloid deposition in patients with long term haemodialysis usually takes place in?
a. Renal vessels
b. Peripheral nerve
c. Knee joint
d. Carpal tunnel
12. AA amyloid chain is found in:
a. Multiple myelomas
b. Gout
c. Familial Mediterranean fever
d. Alzheimer disease
13. The lardaceous spleen is due to deposition of amyloid in
a. Sinusoids of red pulp
b. White pulp
c. Penicillary artery
d. Splenic trabeculae
14. A 60 years old female is suffering from renal failure and is on haemodialysis since the last 8 years.
She developed carpal tunnel syndrome. Which of the following will be associated?
a. AL
b. AA
c. ATTR
d. Beta 2 microglobulin
15. “Lardaceous” spleen is seen in:
a. CML
b. Hodgkin’s lymphoma
c. Amyloidosis
d. Malaria
16. Protein deposited in familial amyloid neuropathy
a. Mutated transthyretin
b. Normal transthyretin
c. Mutated beta-1
d. Mutated beta-2
17. Serum amyloid associated protein found in:
a. Alzheimer’s disease
b. Chronic inflammatory states
c. Chronic renal failure
d. Malignant hypertension
18. The most common cause of death in primary amyloidosis is?
a. Respiratory failure
b. Cardiac failure
c. Renal failure
d. Septicemia
19. In amyloidosis Beta pleated sheet will be seen in:
a. X-ray crystallography
b. Electron microscope
c. Spiral electron microspore
d. Congo red stain
20. Depositions of protein A beta 2 microglobulin is seen in which clinic-pathologic category of
amyloidosis
a. Familial Mediterranean fever
b. Haemodialysis-associated
c. Senile cerebral
d. Systemic senile
21. Best investigation for diagnosing amyloidosis
a. Rectal biopsy
b. Colonoscopy
c. CT scan
d. Upper GI endoscopy
22. Which of the following is Heredofamilial amyloidosis?
a. Alzheimer’s disease
b. Multiple myelomas
c. Familial Mediterranean fever
d. Systemic senile amyloidosis
23. Sago spleen is seen in:
a. Gaucher’s disease
b. Malaria
c. Amyloidosis
d. Felty’s disease
24. Stains used in Amyloidosis
a. Congo red
b. Thioflavin
c. Reticulin
d. Gram’s iodine
e. PAS
