HEMATOLGY ASCP
Question Answer
what cell shape is most commonly associated with idiopathic
iron overload in tissue
hemochromatosis
a patient with polycythemia vera who is treated by phlebotomy is most
iron
likely to develop a deficiency of
The direct antiglobulin test is often positive in acquired hemolytic anemia
the hypoproliferative red cell population in the bone marrow of uremic decreased levels of circulating
patients is caused by erythropoietin
which of the following characteristics are common in H.spherocytosis, H.
red cell membrane defects
Elliptocytosis,H.stomatocytosis and paroxysmal nocturnal hemoglobinuria
The most likely cause of the macrocytosis that often accompanies anemia of
folic acid deficiency
myleofibrosis is
what is associated with megaloblastic anemia neutropenia and thrombocytopenia
relative polycythemia associated with
what type of polycythemia is severely burned patient most likely to have
dehydration
which of the following is seen in lead poisoning basophilic stippling
Giant vacuolated, multi erythroid precursors are present in which erythroleukemia
what is a significant feature of erythroleukemia/ acute erythroid
megaloblastoid erythropoiesis
leukemia(DiGuglielmo Syndrome)
M:E ratio in erythroleulemia is usually low
what is increased in erythrocytosis secondary to a congenital heart defect erythropoietin
what is a characteristic of polycythemia vera decreased or absent bone marrow stores
which of the RBC indices is a measure of the amount of hemoglobin in
MCH
individual red blood cells
The RDW-CV and RDW-SD performed by automated cells counters are an index of the distribution of RBC
calculations that provide volumes
the laboratory tests performed on a patient indicate macrocytosis, anemia vitamin B12 deficiency/ megaloblastic
leukopenia and thrombocytopenia. what would the patient most likely have anemia
Wright -staine anema smear would most likely show normocytic, hypochromic,erythrocytes
Evidence of active red cell regeneration may be indicated on a blood smear basophilic stippling, NRBC,
by polychromasia/accelerated heme
HEMATOLGY ASCP
synthesis
characteristics PB morphploogic feature in multiple myeloma is rouleaux formation
in polycythemia vera, the hemoglobin, HCT, RBC count and red cell mass are elevated
M;E ration in polycythemia vera sis usually normal to slightly elevated
ringed sideroblasts, nuclear dudding and
what is most closely associated with erythroleukemia
howell- jolly bodies
an increased amount of cytoplasmic basophilia in a blood cell indices
decreased cytoplasmic maturation
indicates
the term shift to the left refers to immature cell forms in PB
A term that means varying degrees of leukocytosis with a shift to the left
leukoerythroblastosis
and occasional NRBC in the PB
Cells that produce antibodies and lymphokines lymphocytes
The PB monocyte is an intermediate stage in the formation of the fibroblast
specific (secondary )granules of the neutrophilic granulocyte appear first at the myelocyte stage
Elevation of the total granulocyte count above 7.7x 10^3.ul(7.7x19^9/L) is
absolute neutrophilic leukocytosis
termed
Elevation of the granulocyte percentage above 75% relative neutrophilic leukocytosis
Elevation of the total white cell count above 12x10^3 is termed leukocytosis
elevation of lymphocyte percentage above 47% relative lymphocytosis
Terminal deoxynucleotidyl transferase (TdT) is a marker found on lymphoblasts
Multipotent stem cells are capable of producing lymphoid and myeloid stem cells
long are chromosome 22 and long arm
the phili chromsome is found by translocation between
chromosome 9
a shift in granulocytes from the
mechanism of cortisol- induced neutrophilia include
marginating pool to the circulating pool
which cells are involved in immediate hypersensitivity reactions basophils
feature of pernicious anemia hypersegmentation
which of the following conditions is not associated with high incidence of
megaloblastic anemia
leukemia
M;E ration in chronic myeloctyic leukemia is usually high
HEMATOLGY ASCP
in FAB classification, myelomonocytic leukemia would be M4
abnormalities found in erythroleukemia include megaloblastoid development
neutropenia is not associated with hodgkin disease
Auer rods are most likely present in acute myelocytic leukemia
Dwarf or micro megakaryoctes may be found in the PB of patients with myelofibrosis with myeloid metaplasia
which is associated with pseudo-pelger-huet anomaly myelogenous leukemia
predominately found in acute
Auer bodies are
myelogenous leukemia
the absence of the PH' chromosome in granulocytic leukemia suggest rapid progression of the disease
Increased numbers of basophils are often seen in chronic myelocytic leukemia
a hypercellular marrow with M;E ratio of 6;1 is most commonly due to granulocytic hyperplasia
which is the most predominant form of secondary hematologic malignancy
acute myelomonocytic leukemia
seen in patients with multiple myeloma
in chronic myelocytic leukemia, blood histamine concentrations tend to
number of basophils present
reflect the
biochemical abnormalities characteristics of polycythemia vera include increased serum B12 binding capacity
are lysosome and acid phosphatase
Auer rods
positive
50%-90% myeloblasts in a PB is typical in acute myelocytic leukemia
The M: E ratio in acute myelocytic leukemia/AML is high
most closely associated with chronic myelomonocytic leukemia lysozymuria
the absence of intermediate maturing cells between the blast and mature
neutrophil commony seen in acute myelocytic leukemia and myelodysplastic leukemic hiatus
syndromes is called
most closely associated with chronic myelogenous leukemia/CML philadelphia chromosome
The bone marrow in the terminal stage of erythroleukemia is often
acute myelocytic anemia
indistinguishable from that seen in
A block in the difference of maturation of, and an accretion of immature
acute myelogenous leukemia
hematopoietic progenitors is a hallmark of
HEMATOLGY ASCP
all stages of neutrophils are most likely to be seen in the peripheral blood of
chronic myelocytic leukemia
a patient with
myelocytic leukemia, polycythemia
conditions of myeloproliferative disorders
leukemia, idiopathic thrombocythemia
A patient has a tumor that concentrates erythropoietin. He is most likely to
poltcythemia associated with renal disese
have which of the following types of polycythemia
what type of polycythemia is most often associated with emphesema polycythemia,secondary to hypoxia
hemorrhage in polycythemia vere is result of abnormal platelet function
a patient diagnosed with polycythemia 5 years ago NOW has a normal HCT,,
phlebotomy
decreased HBG and microcytic, hypochromic red cells. what is this cause
are morphologically more variable
in comparison to malignant lymphoma cells, reactive lymphocytes
throughout smear
T-cell acute lymphocytic leukemia (ALL) is closely related to lymphoblastic lymphoma
ine the FAB classification, acute lymphocytic leukemia is divided into groups
morphology
according to
increased levels of TdT activity are indicative of acute lymphocytic leukemia
massive accumulation of primitive lymphoid- appearing cells in bone
acute lymphoblastic leukemia (ALL)
marrow is true for what
the most common form of child hood leukemia acute lymphocytic leukemia(ALL)
accumulation of monoclonal B cells with a
chronic lymphocytic leukemia is
block in cell maturation
Hairy cells leukemia(leukemic reticuloendotheliosis) is a chronic leukemia of lymphocytic origin
pancytopenia,monoclear cells with ruffled
characteristics of hairy cell leukemia
edges,splenomgaly
increased resistance to infection is not a charateristic of what hairy cell leukemia
morphologic variants of plasma cells include flame cells, morula cells, grape cells
gaucher cells are not morphology of what cell plasma cell variants
what favors the diagnosis of multiple myeloma sheaths of immature plasma cells
what has a B cell origin waldenstrom macroglobulinemia
most likely identified in lesions of mycosis fungoides T lymphocytes
chronic lymphocytic leukemia cells are most likely to express which of the CD19,CD20,CD21,CD5
HEMATOLGY ASCP
following cell surface markers
which of the following markers typically detected in normal myeloid cells,
CD11c
are expressed on the surface of hairy cell leukemia lymphicyetes
surface marker that is expressed in neoplastic plasma cells and is helpful in
CD138
the diagnosis of myeloma is
