COSMETIC PRESERVATIVES
ISCAGUARD SAP ®
Revolutionary, Natural & Antimicrobial
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Preserving the tradition
Iscaguard® SAP – Revolutionary, Natural & Antimicrobial
Iscaguard® SAP
Technical Information:
• Product Code: SAP
• INCI Name: Salix Alba
Willow Bark Extract,
Propanediol
• INCI Status: Approved
• Suggested Use Levels: 1.0–10.0%
• Suggested Applications:
Natural Preservation
Exfoliation
Problem Skin
Antidandruff
Antimicrobial & Soothing
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Preserving the tradition
Iscaguard® SAP – Revolutionary, Natural & Antimicrobial
Iscaguard® SAP
Antimicrobial Effects:
20%
Salicylic acid has been The bark of the Iscaguard SAP is
identified as part of Black Willow, used standardized for 20%
a plant’s endogenous interchangeably with Salix salicylates
defence mechanism alba or White Willow, is a
against invading source of salicylic acid
pathogens
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Preserving the tradition
Iscaguard® SAP – Revolutionary, Natural & Antimicrobial
Iscaguard® SAP Efficacy Assay Results
Protocol
The zone of inhibition for 2.00%
Iscaguard® SAP was determined in relation
to the zones of inhibition for 1.00%
Salicylic acid and Butylene glycol against
both S. aureus and P. acnes.
Iscaguard® Decylene
Salicylic Acid
SAP Glycol
6 mm 7 mm 1.5 mm
Results
Iscaguard® SAP was as effective as 1.00%
Salicylic Acid in inhibiting the growth of
S. aureus
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Preserving the tradition
Iscaguard® SAP – Revolutionary, Natural & Antimicrobial
Iscaguard® & P. acnes efficacy
Protocol
The zone of inhibition for 2.00%
Iscaguard® SAP was determined in relation
to the zones of inhibition for 1.00%
Salicylic acid and Butylene glycol
against P. acnes
Iscaguard® Decylene
Salicylic Acid
SAP Glycol
3 mm 4.5 mm 1.5 mm
Results
Iscaguard® SAP was as effective as 1.00%
Salicylic Acid in inhibiting the growth of
P. acnes
OH
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Preserving the tradition
Iscaguard® SAP – Revolutionary, Natural & Antimicrobial
Salicylic Acid & UV Damage
Salicylic acid has been found to
significantly inhibit UVB induced
NF-kb activation in keratinocytes.
NF-kb (Nuclear Factor Kappa B) is a cell
signalling molecule for inflammation.
Its activation induces the expression
of COX-2, which leads to tissue
inflammation
Salicylic acid was also found to have
an anti-inflammatory effect on normal
keratinocytes
Reference: Mammone, Thomas. et.al. (Estee
Lauder Companies) Salicylic Acid Protects the
Skin from UV Damage. Society of Cosmetic
Chemists Annual Scientific Meeting and
Technology Showcase
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Preserving the tradition
Iscaguard® SAP – Revolutionary, Natural & Antimicrobial
Iscaguard® SAP Efficacy Assay Results
Protocol Conclusion
• 15 female test subjects 2.00% Iscaguard SAP was more effective
• Control: 5.00% Petroleum base Dansyl than 1.00% Synthetic Salicylic Acid in
Chloride solution increasing cellular renewal
• Test materials:
a. 1.00% Synthetic Salicylic Acid
(aqueous solution pH 3.90)
b. 2.00% Iscaguard® SAP
• UV light was used to determine the colour
intensity relative to the level of binding
and percent increase in cell renewal
Percent % Increase in cell renewal
Iscaguard® Synthetic
Control
SAP Salicylic acid
25% 20% 1%
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Preserving the tradition
Iscaguard® SAP – Revolutionary, Natural & Antimicrobial
Iscaguard® SAP
Benefits:
Enhances cell Replacement Natural Exfoliates Treats
turnover for synthetic Preservation Problem Skin
salicylic acid
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Preserving the tradition
