BIOPHARMACEUTICALS: The Future of Healthcare PROBIOTICS Product Portfolio FAME Pharmaceuticals Industry Co., Ltd.What are PROBIOTICS? Our bodies are home to trillions of bacteria. It was previously thought that most were just harmless organisms that have evolved to coexist within us but emerging research has shown the critical roles they play in our wellbeing. In short, probiotics are the good and friendly bacteria that help keep our bodies healthy and well-functioning. How do they work? The average person has around 1.5 kg of bacteria that help with digestion and keep the stomach in balance. They do this by producing substances that inhibit the growth of unwanted bacteria, occupying the epithelial cells in the gastrointestinal tract and fighting for space and nutrients. In this way, humans and their gut microbiota share a symbiotic relationship. e ° However, many activities in our modern lifestyle can upset the balance of our microflora. For example; taking antibiotics, consuming ultra-processed foods, not getting enough sleep, smoking and drinking too much alcohol Without proper rehabilitation, it is easy for the harmful bacteria to become the dominant force in our systems. Probiotics help mitigate this by replenishing and reinforcing our gut microbiota with the good bacteria of our choice to get the desired health benefits.Types of PROBIOTICS The average person has over 1000 species of bacteria in their gut microbiome and different types of probiotics can have different effects on our bodies. Therefore, it is important to choose the probiotic strains that are most suitable for your needs in order to maximise effiency. Although most are still being studied, a number of probiotic strains are now scientifically proven to have desired benefits. You will find our carefully selected high performing strains present in our products below. yy Cos 4 ‘\ Z Y‘X FG ~ i4 X £ <5"= Biogurt Pro 's Supplement @ Biogurt’ © Prevention and treatment of diarrhoea aad © Restore normal flora after " diarrhoea or antibiotic therapy | © Irritable bowel syndrome (IBS) © Immunoenhancement Each capsule contains: @ @ Bifidobacterium lactis - 875 million Lactobacillus acidophilus - 875 million 2° = 9 probiotics that Improves recovery after antibiotic improves gut microflora and reduces treatment, repopulating the gut with the number of unwanted bacteria. good bacteria to re-establish a healthy Clinically proven strong strains. balance of bacteria. = Helps digestion and reduce flatulence; Improves lactose intolerance and foods exposed to these bacteria are absorption of calcium containing foods. broken down and will have their biological values improved.Each capsule contains: @ @ @ Lactobacillus rhamnosus - 1 billion Bifidobacterium bifidum - 1 billion Streptococcus thermophilus - 1 billion ees Lactic acid bacteria are beneficial bacteria that exist naturally in the intestines Lactobacillus rhamnosus, in particular, is recognized for its ability to survive passage through the acidic Gl tract and inhibits harmful bacteria that prefer alkaline surroundings. It is excellent for intestinal colonization and has anti- inflammatory effect controlling cytokines. It has been shown to have a positive effect on the oral immune response and may also reduce the colonization of oral bacteria. It also supports healthy skin and vaginal health, Probiotics for Immunoen| BioMune Helps strengthen the immune system. Supports healthy skin and oral health Helps maintain a healthy digestive system ‘© Improves absorption of nutrients NO NEL ACY Rae ed eet) Pe eC hat ees eye Rl Pan tsa Bifidobacteria are active scavengers of toxins and helps remove toxic substances from the body, thus supporting liver functions. Bifdobacterium bifidum is the most dominant probiotics in the large intestine that has ability to break down complexcarbohydrates, fats and proteins so that the body can use them more efficiently. It also supports the production of vitamins. Streptococcus thermophilus rapidly grows in the intestine and helps Lactobacillus and Bifidobacterium to settle. It is an important and hardy strain that supports colon health by protecting against small intestine initation * Regular consumption of these probiotics helps maintain a healthy immune system by modulating immune responses.BioBeauty memes © Enriches skin for healthy and smooth appearance © Helps reduce UV-induced skin damage © Maintains skin youthfulness © Skin detoxification Each capsule contains: © @ @ @ . . on Me oe ea) Lactobacillus casei - 2.4 billion CFU Bgniicantictelinterscessina Lactobacillus plantarum - 1.2 billion CFU skin proteins, free fatty acids Cor es en a) Cen ee i ereeis Lactobacillus rhamnosus - 1.2 billion CFU Bifidobacterium lactis - 1.2 billion CFU Probiotics promote the absorption of dietary nutrients that are essential for cell metabolism and synthesis of various functional ‘and structural components of the skin. Probiotics also help inhibit aggressive pathogens that provoke infections in the skin through competitive exclusion and other mechanisms such as lowering pH to preserve skin health. Lactobacillus probiotics helps preserve procollagen in human 4 P) fibroblasts. It also significantly enhances hyaluronic acid synthesis in the skin, This improves skin elasticity, increases moisture content in the skin and reduces signs of facial aging.GD ‘ol Cholesterol Loweringholesterol Lowering Prol © Supports fat burning © Promotes healthy weight loss © Modulates energy metabolism © Helps dissolve gallstones Each capsule contains: @@@@ . INS sd Lactobacillus acidophilus - 1.5 billion CFU Cer ee ei Lactobacillus casei - 1.5 billion CFU Pounce eae ea as \ errs Lactobacillus plantarum - 1.5 billion CFU Pediococcus pentosaceus - 1.5 billion CFU These probiotics are highly effective in degrading cholesterol. They possess hypocholestrolemic effects which allows them to bind cholesterol in the small intestine. The bound cholesterol is used for growth or converted to coprostanol which is directly excreted from body. This lowers dietary cholesterol available for absorption in the instestine. Probiotics ferment non-digestible polysaccharides and produce short-chain fatty acids which interact with G-protein coupled receptors to reduce gut motility and suppress energy intake. These interactions also stimulate leptin production which inhibits obesity- related metabolic disturbances such as insulin resistance and lipogenesis. Probiotics are also able to deconjugate bile acids by producing bile salt hydrolases (BSH). Deconjugated bile acids are poorly absorbed and mostly excreted from the body.torte BioKid '® Boosts immunity & tummy comfort ee © Supports growth of bones & teeth © Supports digestive health © Reduces incidence of respiratory infections Each chewing tablet contains: @ @ @ Cee oer) Sireplococcus thermophilus - 3.6 billion CFU Cee clic Te eso ur Ret eS RRs cu Lactobacillus acidophilus - 1.2 billion CFU Bifidobacterium longum - 1.2 billion CFU Probiotics are safe and effective as a treatment for children with acute infectious diarrhoea, antibiotic-associated diarrhoea, constipation and abdominal pain. 9 Studies have shown Children consuming milk Probiotics can also help dietary intake of containing this probiotic Prevent acute respiratory probiotics to be also had significantly tract infections and beneficial in terms of fewer dental caries and reduce symptoms of the weight and height gain lower salivary counts of common cold. among children. harmful bacteria that cause tooth decay, Although BioKid is intended for children, the constituents of BioKid (Lactobacillus acidophilus, Bifidobacterium longum, Streptococcus thermophilus) are also suitable for patients with Chronic Kidney Disease (CKD). According to international research, probiotic strains included in BioKid can improve renal function, reduce metabolic parameters such as cholesterol and have anti-oxidant action. Thus, it is also suitable for patients on hemodialysis.Each lozenge contains: @®@®@ CC® Streptococcus thermophilus - 2.5 bilion CFU BioOral Lakhs OKLA t Lh) @ Improves gums and teeth health © Promotes better breath © Promotes oral immune health © Restores oral flora Tee ag De Ce ag Bifidobacterium breve - 0.83 billion CFU (ofenne aD Dalene Lactobacillus rhamnosus - 0.83 billion CFU eM Lactobacillus casei - 0.83 billion CFU Pee eee LC ney Dee ae ies Set Lactobacillus paracasei - 0.83 billion CFU cele Lactobacillus reuteri - 0.21 billion CFU Probiotics protect oral health by inhibiting pathogenic bacteria in the oral cavity. They directly compete for space needed for attachment and also produces bacteriocins that suppress the growth of harmful bacteria. This controls the number of Streptococcus mutans, the main bacteria that causes dental caries. They also induce immune responses such as salivary IgA formation, macrophage activation and modulation of pro- inflammatory cytokines, producing vitamins and lactic acid that function as antioxidants. These antioxidants prevent stain and plaque formation by limiting mineral formation Probiotics also lower the pH so that microorganisms cannot form plaques and calculus that cause oral inflammation.[ola ideals) (Pre rea a = Prob © Improves neurodegenerative and neurodevelopmental disorders © Helps reduce muscle rigidity and postural instability ‘© Immunomodulation and energy balance Each capsule contains: @ @ @ © iL Ur 7 Co a Meee aurea Bifidobacterium bifidum - 1.7 billion CFU Draenei Onn Lactobacillus acidophilus - 1.7 billion CFU =a) fore emu eels , De eRe Lactobacillus plantarum - 1.7 billion CFU Penn aes cane ny Lactobacillus reuteri - 0.86 billion CFU both the ENS and CNS. Studies have now proven gut microbiota to either directly or indirectly modify brain neurochemistry through neural, immune and endocrine systems. Probiotics intake can reduce behavioral and cognitive deficits such as anxiety, depression and memory problems while improving levodopa absorption. It can also increase neuronal membrane formation and function and reduce inflammation in both the enteric nervous system (ENS) and central nervous system (CNS). This helps (2) =z reduce motor and non-motor abnormalities in Parkinson's disease. st Probiotics play a crucial role in regulating production of ‘microbial metabolites and activation of the vagus nerve in neurodegenerative and neurodevelopmental disorders.Superior Coating Technology No matter how many probiotics a person takes, they cannot work if they do not reach out intestines alive. However, to do that, they need to pass through the harsh acidic conditions of the stomach. Our probiotics are double coated with a unique and patented coating technology optimized for protecting them against harsh external and internal environmental conditions. This ensures they reach their destination alive and hence, the efficacy of the product. 1st coating layer 2nd coating layer consists of a peptide or consists of a hydro-colloidal protein matrix polysaccharide matrix Probiotics DUAL COATED PROBIOTICSOur Products Biogurt BioMune BioBeauty BioFat BioKid BioOral BioParFAME Pharmaceuticals Industry Co., Ltd. CONTACT ADDRESSES Yangon = 20, Mingyi Mahar Min Gaung Street, Industrial Zone 3, (Office) Hlaing Tharyar Township, Yangon, Myanmar. Ph 101-368 5609, 368 2199, 368 5083, 09-443 142 216 Fox 01-368 0122 Email: drkmI@famepharma.com Pyin Oo Lwin - Fame Organic Pharming Project 706, Kywal Nar Htauk Village, near Anee-sa-khan Railway Station, Pyin Oo Lwin Township, Mandalay Region, Myanmar. Ph : 09-793 877 207 Singapore - FAME Pharma Pte Ltd. (Office) 7 Sin Ming Walk, #05-14 The Gardens @ Bishan, Singapore 575577 Ph 1 +65-8112 5454 Email : mam@famepharma.com.sg www.famepharma.com.sg Singapore - 111 North Bridge Road, #04-51 Peninsula Plaza, (Showroom & — Singapore 179 098 Sales Center) Ph: +65-9457 0530 FAME DELIVERY SERVICE - 09-95 500 5000 09-75 273 1908, 09-75 284 1908, 09-96 512 1908, 09-98 521 1908 Copyright © 2022 Issue ~2 (July) www.famepharma.com [J FAME Pharmaceuticals FAME]