MBBS 2nd PROF

PHARMACOLOGY
Sample Paper: PAPER-B, BFUHS
TIME:3 Hours Max Marks: 100

Q1. Multiple Choice Questions, Use OMR sheet to answer, 1x20=20, Time for MCQs-30 min

1. A 55-year male patient with osteoarthritis is being prescribed corticosteroid. Which of

the following disease history must be asked by the prescriber before giving the
prescription?
A. Peptic ulcer
B. Anaemia
C. Bronchial asthma
D. Anxiety
2. A 52-year female was prescribed alendronate for osteoporosis. However, the prescriber
told her special instructions to take the drugs empty stomach with at least with 300ml
ml of water, standing and not to lie down after and not to eat anything for 30 minutes
after taking it. Which of the following is the reason for these instructions?
A. To prevent flu-like symptoms
B. To increase bioavailability
C. To prevent hypotension
D. To prevent oesophagitis
3. A couple has asked to you for post-coital contraception and 4 days are already over
after unprotected exposure. Which of the following drugs can be useful in this scenario?
A. Levonorgestrel
B. Ulipristal
C. Norgestrel
D. Norethindrone
4. A pregnant female needs to be prescribed antithyroid drugs. Which of the following is
the safest option?
A. Carbimazole
B. Iodide
C. Propylthiouracil
D. Radioactive iodine
5. 50-year diabetic male manifested sign symptoms of hypoglycemia while in hospital
chair. Patient is becoming drowsy and stopped responding to verbal commands. Which
of the following agent in will be useful immediately in this scenario before other help
arrives?
A. 50% dextrose
B. Hydrocortisone
C. Propranolol
D. Metformin
6. An anaemic child was prescribed oral iron syrup for 3 months. To mask the taste child’s
mother gave it with milk every day. After 3 months there was only a slight improvement
in anaemia. Which of the following can be the reason for this?
A. Milk decreases absorption of iron
B. Milk increases excretion of iron
 C. Milk increase utilisation of iron in body
D. Iron loses its efficacy in presence of milk
7. A 48-year woman came to the gynaecology OPD with a history of heavy menstrual
bleeding. She complained of having to change 4-5 pads in a day and increase in
bleeding for more than seven days since last four months. Which of the following is
the preferred drug that can be given to the patient?
A. Mefenamic acid
B. Tranexamic acid
C. Aminocaproic acid
D. Acetylsalicylic acid
8. A 60-year male patient presented with haemorrhagic cystitis after receiving
cyclophosphamide. Which of the following drug is recommended in this scenario?
A. Methylene blue
B. N-acetylcysteine
C. 2-Mercaptoethane sulfonate sodium
D. Para-amino-benzoquinone imine
9. A 60-year male presents with cough, expectoration, evening rise of temperature since
last 3 weeks. Sputum tests positive for AFB. Which of the following is among first line
drug in this case?
A. Moxifloxacin
B. Ethionamide
C. Ethambutol
D. Cycloserine
10. A 20-year girl presents with episodes of high-grade fever with rigors and chills for last
three days. PBF shows intraerythrocytic Plasmodium vivax. Which of the following
drugs is used for radical cure in this case?
A. Chloroquine
B. Primaquine
C. Sulfadoxine-pyrimethamine
D. Artesunate
11. A 42-year female presents with vaginal itching, foul smelling rothy discharge and
dysuria. High vaginal swab tests positive for trichomoniasis. Which of the following is
drug of choice in this patient?
A. Oral metronidazole
B. Oral ketoconazole
C. Intravaginal povidone iodine
D. Intravaginal clotrimazole
12. A 52-year female was on antihypertensive drugs for last 4 years. She was prescribed
a different drug now as blood pressure control was not good. Treating physician called
her for review after 3 months. Her reports show elevated serum potassium levels and
decreased GFR. Which is causative drug and what precaution is required to be taken in
this case?
A. Chlorthalidone- monitoring needs to be done every month after initiation.
 B. Metoprolol-monitoring needs to be done every month and after each dose
increase.
C. Amlodipine- monitoring needs to be done after 1 month of initiation and after
every dose increase.
D. Losartan- monitoring needs to be done after 1 week of initiation and after
every dose increase.
13. Acute attacks of Paroxysmal supraventricular tachycardia (PSVT) are usually
controlled by non-pharmacological measures. However, in acute attacks
pharmacotherapy is needed. Which of the following drug is preferred in PSVT?
A. Amrinone
B. Adenosine
C. Amiodarone
D. Digitalis
14. A 56-year Asian man presents with dyspnoea on walking a few meters. He has got
pitting edema feet and bilateral basal crepts are heard on chest auscultation. He has a
long history of poorly controlled hypertension. A diagnosis of Heart Failure is made.
Which of the following is drug of choice out in this condition?
A. Metoprolol
B. Ramipril
C. Isosorbide dinitrate
D. Hydralazine
15. A 52- year patient is having frequent attacks of angina pectoris. For treatment of acute
attack, he has been prescribed sublingual Nitroglycerine. To prevent the frequent
attacks of Angina pectoris, which of the following drug can be useful?

A. Amyl nitrite
B. Esmolol
C. Sublingual Isosorbide dinitrate
D. Verapamil
16. Nifedipine was once drug of choice in hypertensive emergencies. However,
Nifedipine is not preferred in hypertensive emergencies in a cardiac disorder patient.
Which of the following best describes the reason for this?
A. Heart blocks
B. Reflex tachycardia
C. Diastolic cardiac arrest
D. Systolic cardiac arrest
17. A 70-year-old patient presented with weakness, tiredness and muscle cramps. His
serum K+ was low (2.8 mEq/L), while serum sodium levels were found to be within
normal limits. He admitted to taking a laxative every day for the past several months.
Which of the following drug is the most likely cause for the above condition?
A. Bisacodyl
B. Liquid paraffin
C. Methylcellulose
D. Bran
 18. An 8-year child was administered an injection to control his vomiting. A few hours
after administration of the drug, he developed loose stools and muscle dystonia. Which
of the following drug is the most likely cause for the above condition?
A. Domperidone
B. Mosapride
C. Metoclopramide
D. Ondansetron
19. A 48-year patient is brought to hospital with iron poisoning. Which of the following
drug is contraindicated in this patient?
A. Deferiprone
B. Penicillamine
C. Desferrioxamine
D. Dimercaprol
20. A patient with G6PD deficiency needs chelating agent. Which of the following
cheating agent is contraindicated in this patient?
A. Deferiprone
B. Penicillamine
C. Desferrioxamine
D. Dimercaprol

Q 2. Long essay question 4+4+4=12

Classify oral antidiabetic agents. Describe mechanism of action & adverse effects of
Metformin.
.
Q 3. Short answers: 5x4=20
a) Enumerate antiemetics and describe their mechanism of action
b) Describe therapeutic uses and adverse effects of ACE (angiotensin converting
enzyme) inhibitors.
c) Describe therapeutic uses of antiplatelet drugs
d) Briefly describe iron chelators

Q 4. Explain why: 3x5=15

a) Statins are used in hyperlipidaemias
b) Nitrates are used in angina
c) Drug dose is changed for some drugs in geriatric age subjects
d) Treatment with glucocorticoids should not be abruptly stopped
e) Bisphosphonates are used in osteoporosis

Q 5 Short answers (applied aspects): 6x3 =18

a) Describe management of new case of pulmonary tuberculosis .
b) Describe management of hypertensive emergencies.
c) COVID-19 vaccines: types and their status
Q 6 Short answers: 5x3 =15
a) Describe therapeutic uses and adverse effects of chloroquine
b) Describe post-exposure prophylaxis after needle stick injury from HIV+ patient
c) Describe principles of bioethics