Fungal Questions
43
5
’s Teamwork
Respiratory Block
● The document includes SAQ scenarios and MCQs.
● Please contact the team leaders for any suggestion, question or correction.
Microbiology.435@gmail.com
MCQs
Q1: Which of the following sentences is true:
A | Respiratory viral infections are less common than fungal and bacterial infections.
B | Respiratory fungal infections are less common than viral and bacterial infections.
C | Respiratory bacterial infections are less common than viral and fungal infections.
Q2: Which of the following is opportunistic respiratory fungal infection:
A | Mucor
B | Coccidioides immitis
C | Cryptococcus neoformans
D | C. gattii
Q3: Which of the following is primary respiratory fungal infection:
A | C. gattii
B | Rhizopus
C | Blastomyces dermatitidis
D | Mucor
Q4: Dimorphic fungi cause:
A | zygomycosis
B | Aspergillosis
C | Primary Systemic Mycoses
D | Pneumocystis (PCP)
Q5: Aspergillus species are:
A | Mould fungi
B | Dimorphic fungi
C | Yeast
D | Primary infections
Q6: Which of the following diseases show halo sign in radiology:
A | Pulmonary zygomycosis
B | Chronic Aspergillosis (Colonizing aspergillosis)
C | Invasive pulmonary Aspergillosis
D | Rhinocerebral zygomycosis
Q7: Which of the following diseases show radiolucent crescent in radiology:
A | Chronic Aspergillosis (Colonizing aspergillosis)
B | Invasive pulmonary Aspergillosis
C | Pulmonary zygomycosis
Q8: The most common cause of fungal sinusitis in KSA is:
A | Aspergillus nidulans
B | Aspergillus niger
C | Aspergillus terreus
D | Aspergillus flavus
Q9: Which of the following you will see under the microscope in Aspergillosis:
A | fungal septate hyphae
B | Nonseptate hyphae
Q10: Which of the following treatment is used in aspergillosis:
A | Sulfamethoxazole
B | Trimethoprim
C | Voriconazole
D | Dapsone
Q11: Which of the following you will see under the microscope in Pulmonary
zygomycosis:
A | Septate hyphae
B | Nonseptate hyphae
Q12: Which of the following is true about Pulmonary zygomycosis:
A | Acute
B | Chronic
C | Infection can not extend to other organs
Q13: Which of the following is a treatment of Pulmonary zygomycosis:
A | sulfamethoxazole
B | Trimethoprim
C | Caspofungin
D | Amphotericin B
Q14: Which of the following diseases is common in AIDS patients:
A | Chronic Aspergillosis
B | Allergic bronchopulmonary (ABPA)
C | Pulmonary zygomycosis
D | Pneumocystis (PCP)
Q15: Which of the following organism cause Pneumocystis:
A | Pneumocystis jiroveci
B | Rhizopus
C | Aspergillus flavus
D | Histoplasmosis
Q16: Which of the following is a treatment of Pneumocystis:
A | Itraconazole
B | Caspofungin
C | Trimethoprim
D | Amphotericin B
Answer key: ( Q1:
B
Q2:
A
Q3:
C
Q4:
C
Q5: Q6:
A C
Q7: A Q8: D
Q9:
A
Q10:C Q11:BQ12:
AQ13:
D Q14:
D A
Q15: Q16:
C)
SAQs
A 32 man came to KKUH complaining about fever, hemoptysis, cough, leukocytosis, the
radiology test show lesions with a halo sign.
1 What can be the diagnosis?
Invasive pulmonary Aspergillosis.
2 What kind of specimens you will take?
Sputum, BAL, Lung biopsy.
3 What will you see under the microscope? and what is the stain you will use?
Fungal septate hyphae, Giemsa Stain, Grocott methenamine silver stain (GMS).
What further tests can you do?
4
Test for Antibody, ELISA test for galactomannan Antigen.
5 Name one medication used to treat this case?
Voriconazole.
6 What are the diseases included in Aspergillosis:
Mycotoxicosis, Allergy, Colonization (without invasion and extension ) in preformed
cavities, Invasive disease of lungs, Systemic and disseminated disease
What are the risk factor of Aspergillosis:
7
Bone marrow or organ transplantation. AIDS. Diabetes. Cancer: Leukemia, lymphoma.
Drugs: Cytotoxic drugs, steroids.
8 Name two common airborne Fungi:
Aspergillus niger, Aspergillus fumigatus.
9 Name two Primary Systemic Mycoses:
Histoplasmosis, Blastomycosis, Coccidioidomycosis, Paracoccidioidomycosis
List some symptoms and signs seen in Allergic bronchopulmonary (ABPA):
10
Symptoms of Asthma, Bronchial obstruction, Fever, malaise, Eosinophilia, Wheezing,
Skin test reactivity to Aspergillus, Serum antibodies to Aspergillus, Serum IgE > 1000
ng/ml, Pulmonary infiltrates.
