M.M.
COLLEGE OF PHARMACY
MAHARISHI MARKANDESHWAR (DEEMED TO BE
UNIVERSITY), MULLANA, AMBALA, HARYANA (India)133207
(Established under section 3 of UGC, act 1956)
(Accredited by NAAC with Grade ‘A++’)
3rd Semester B. Pharm Question bank (Section-A)
Subject- BP 301T Pharmaceutical Organic Chemistry-II
Unit One
1) The carbon atoms in a benzene ring are
a) Sp hybridized b) Sp3 hybridized c) Sp2 hybridized d)None
2) Characteristic reaction of aromatic hydrocarbons are initiated by
a) Electrophiles b)Nucleophiles c)Free radicals d)uncharged molecules
3) Which of the following is an incorrect description of benzene?
a) The CCC bond angle are all equal to 120 degree
b) The molecule is Planar
c) Benzene have alternative single and double bond (Carbon-carbon)
d) All Carbon atoms have Sp2
4) The C-C bond length in benzene is
a) Greater than the C-C bond length in ethane
a) shorter than the C-C bond length in ethylene
b) Same as that of C-C bond length in ethylene
c) intermediate between C-C bond length in ethane and C_C bond length in ethylene
5) Which of the following agents is used in order to make benzene react with acetyl chloride to give
acetophenone ?
a) Ultra-Violet light b) AlCl3 catalyst c) platinum catalyst d) Al2O3 catalyst
6) The electrophile which is considered to be active agent in the nitration of benzene is
a) NO2- b) NO+ c) NO2- d) HNO2-
7) Benzene reacts with chlorine in the presence of FeCl3 catalyst
a) Hexachlorobenzene b) chlorobenzene c) hexachlorocyclohexane d) Benzyl chloride
8) Huckel’s rule is (formula)?
a) 4n+4 pi electrons b) 6n+2 pi electrons c) 4n+2 pi electrons d) None
9) DDT is an organic compound and contains how many chloride atoms?
a) 4 b) 3 c) 5 d) 7
10) Which of the following will undergo substitution reaction in the ortho and para positions
Nitrobenzene b) Benzoic acid c) Toluene d) All
Unit-II
Q. 1. On heating aqueous solution of benzene diazonium chloride, which of the following is formed?
a) Benzene b) chlorobenzene c) Phenol d) Aniline
Q. 2. Sodium benzene sulphonate reacts with NaOH and then on acidic hydrolysis, it gives which of the following compound?
a) Phenol b) Benzoic acid c) Benzene d) Disodium benzaldehyde
Q. 3. The characteristic property of phenol and alkyl alcohol is respectively
a) Basic and neutral b) Basic and acidic c) Acidic and basic d) Acidic and neutral
Q. 4. What is the commercial method of preparation of phenol?
a) Dows process b) From diazonium salt c) By decarboxylation of salicylic acid d) Hock method
Q. 5. Reaction of aqueous sodium hydroxide on chlorobenzene gives which of the following products?
a) o-chlorophenol b) o-chlorophenol c) phenol d) no reaction
M.M. COLLEGE OF PHARMACY
MAHARISHI MARKANDESHWAR (DEEMED TO BE
UNIVERSITY), MULLANA, AMBALA, HARYANA (India)133207
(Established under section 3 of UGC, act 1956)
(Accredited by NAAC with Grade ‘A++’)
6. Azo dye is prepared by the coupling of phenol and which of the following compound?
a)Diazonium chloride b)o-nitro aniline c)Benzoic acid d) Chlorobenzene
7. Which of the following method is prepared for the synthesis of aromatic amine except?
a) Gabriel phthalimide synthesis b) Reduction of nitro compound c) Reduction of nitrile with LiAl4 d)
Decarboxylation of amino acids
8 What is A and B in the following chemical reaction?
Conc HNO 3 1. Sn, Conc HCl
A B
+ 2. NaOH solution
a) Aldehyde, nitro compound
b) Nitro compound, phenyl amine
c) Phenyl amine, nitro compound
d) Phenthalene, phenyl amine
9. Which reducing agent is used for the reduction of nitro compound to phenyl amine?
a) LiAlH4 b) Sn/HCl c) Na/alcohol d) H2/Ni
10. that is the general formula of Diazonium salt?
a) RN2+X– b) RN+ c) RXI d) RN2+HSO–2
Unit III
i] Is the yellow colour of the butter due to the presence of pigment?
a) Vitamin-D
b) Carotene
c) Naphthalene
d) Rhodopsin
ii] The unsaturated fatty acid is present mainly in
a) Vegetable Oil
b) fat
c) both oil and fat
d) None of the above
iii] The catalyst used in the hydrogenation of oil is
a) Sodium b) Nickel c)Potassium d)calcium
iv] The formula to find the acid value is
a) 9.61xV(KOH)/W b) 4.61xV(KOH)/W c) 5.61xV(KOH)/W d) 8xV(KOH)/W
v] Which analytical method can the purity test of butter be tested?
a) Saponification value b)acid value c)RM values d) all of the above
vi] Degree of unsaturation of fat can be determined by
a) Saponification value b) acid value c) Iodine value d) acid and iodine values+
vii] Which of the following act as a catalyst in digestive tracts of human beings? a) Lewis acid b) Lewis base c) Hydrogen
peroxide d) Lipases
viii] Oils and fats are good conductors of heat and electricity. a) True b) False
ix] Soaps are _____________ based soapy detergents. a) Water b) Kerosene c) Oil d) Acid
x]Vegetable ghee is manufactured by ____________ a) Saponification b) Hydrogenation c) Oxidation
polymerisation d) Reduction polymerisation
M.M. COLLEGE OF PHARMACY
MAHARISHI MARKANDESHWAR (DEEMED TO BE
UNIVERSITY), MULLANA, AMBALA, HARYANA (India)133207
(Established under section 3 of UGC, act 1956)
(Accredited by NAAC with Grade ‘A++’)
Unit IV
1. Phenanthrene is a fused ring system that contains how many benzene rings?
a) Two b) three c) four d) five
2.Naphthalene undergoes oxidation with Na2Cr2O7/H2SO4 to form
a) Phthalic acid
b) Benzoic acid
c) Teraline
d) Phenyl acetic acid
3.Naphthalene undergoes nitration with HNO3/H2SO4 at 60 °C to give mainly
b) 1-Nitronapthalene
c) 1,2-Nitronapthalene
d) 2-Nitronapthalene
e) 2,5-Nitronapthalene
4. Which of the following is starting material in Haworth’s synthesis of naphthalene
a) succininc anhydride
b) Phthalic anhydride
c) acetic anhydride
d) None of the above
5. Cycloalkanes have similar properties and molecular formulae(C nH2n) respectively
a.)Alkane and alkyne b) Alkane and alkene c)alkene and alkyne d) none
6. Which of the following statement is TRUE in electrophilic aromatic substitution of
naphthalene
a) α-Product forms
b) β-product forms
c) Both α & β product forms
d) α product always predominates depending on the condition
7. Nitration of naphthalene molecule at room temperature gives
a) 1-nitronaphthalene
b) 2-nitronaphthalene
c) 4-nitronaphthalene
d) 8-nitronaphthalene
8. All carbon atoms in naphthalene are
a) Sp hybridised
b) sp2 hybridised
c) sp3 hybidised
d) None of the above
9. Anthracene on reduction in presence of H2/Pd-C gives
a) 9,10 Anthraquinone
b) 9,10 Dihydroanthracene
c) 1,4 Anthraquinone
d) 1,4 Dihydroanthracene
10. Friedel-crafts acylation of phenanthrene gives
a) 1-acetylphenanthrene
b) 4-acetylphenanthrene
c) 9-acetylphenanthrene
d) 10-acetylphenanthrene
M.M. COLLEGE OF PHARMACY
MAHARISHI MARKANDESHWAR (DEEMED TO BE
UNIVERSITY), MULLANA, AMBALA, HARYANA (India)133207
(Established under section 3 of UGC, act 1956)
(Accredited by NAAC with Grade ‘A++’)
Unit-V
1. Identify the compound with the highest angle strain
a) cyclopentane b) cyclobutane
c) cyclopropane d) cyclohexane
2. What is the angle strain in cyclobutane?
a) 24o 44’ b) 19o 22’ c) 20o 44’ d) 26o 44’
3. 1. Cycloalkanes are associated with the general formula called __________
a) CnH2n+2
b) CnH2(n+2)
c) CnH2(n+1-r)
d) CnH2(n+1-r)
4. Which among the following compounds explodes on contact with oxygen?
a) Cyclopropane
b) Cyclobutane
c) Cyclopentane
d) Cyclohexane
5. Identify the incorrect statement regarding cyclohexane.
a) It is non-polar
b) It serves as an organic solvent
c) It a hydrophilic hydrocarbon
d) It is commercially used for variety of application
6. Cycloalkene exhibits aromatic character.
a) True
b) False
7. Identify the incorrect statement regarding cycloalkanes.
a) These have sp3 hybridized carbons
b) These have tetrahedral bond angles
c) Stability of the cycloalkanes varies directly with their respective size
d) These undergo nucleophilic substitution reactions
8. Name the method by which cyclic ketones is converted into cycloalkanes in presence of Zn amulgum and Conc. HCI
a) Wolff-Kishmer reduction
b) Clemmensen’s reduction
c) Diel’s Alder reaction
d) None of above
9. Which of the following cycloalkanes has the least ring strain?
a) Cyclopropane
b) Cyclohexane
c) Cyclopentane
d) Cycloheptane
10. Cyclopropane when reacted with Bromine it gives
a) 1,2-dibromopropane
b) 1,3-dibromopropane
c) 1,4-dibromopropane
d) 1,1-dibromopropane
M.M. COLLEGE OF PHARMACY
MAHARISHI MARKANDESHWAR (DEEMED TO BE
UNIVERSITY), MULLANA, AMBALA, HARYANA (India)133207
(Established under section 3 of UGC, act 1956)
(Accredited by NAAC with Grade ‘A++’)
Short answer type question
1. What is polynuclear hydrocarbon? Could you write down the classification and nomenclature of polynuclear hydrocarbon
(naphthalene and phenanthrene)?
2. What is iodine value? Could you write down the chemical reaction and the significance of the iodine value?
3. What is the Fries rule? Write down the application and stability of anthracene and phenanthrene
Unit-I
1. What do you understand by aromatics compounds give some example and nomenclature
2. What is Huckel’rules ? Write down application and use in aromaticity of compound with examples
3. What is aromaticity? Write down criteria for aromaticity of aromatic compounds
4. What is nitration and sulphonation of aromatic compounds? Give chemical reaction
5. Write down structures and uses of DDT, BHC and Chloramine
Unit-II
Q 1. Give reason why aniline has shown basic property and compared aliphatic and aromatic amine?
Q 2. Write the effect of substituent’s on basicity of aniline? Write the resonating structures of aniline?
Q 3. What is diazotization reaction? Write down the importance of diazonium salts for the synthesis of other organic
compounds
Q 4. Q. Ortho nitrophenol has lower boiling point than p-nitrophenol. Why?
Q 5. Explain the following reactions with an example for each :
(i)Reimer-Tiemann reaction
(ii) Friedel-Crafts reaction
Unit-III
1. What is the triglycerides and write down difference between fats and oils
2. What is hydrogenation of unsaturated lipids? Write down chemical reaction
3. What is iodine value? Could you write down the chemical reaction and the significance of the iodine value?
4. What is RM value? Write down significance of RM value
5. Whats is rancidity of oils? Classify the rancidity
Unit-IV
1. What is polynuclear hydrocarbon? Classify the polynuclear hydrocarbon
2. Write down chemical synthesis and nomenclature of naphthalene
3. Write down chemical synthesis and nomenclature of anthracene
4. What is Fries rule for the stability of compounds and give example with explanation
5. What is Haworth synthesis of naphthalene? Write down each step for naphthalene synthesis (5)
Unit-V
1. What is cycloalkane? Write down example and nomenclature of cycloalkane
2. What is Baeyer’s strain theory? Write down significance and limitation
3. What is Coulson and Moffitt’s modification theory? Write down example and significance
4. What is Banana bond or bending bond for the stability of compounds? Significance and use
5. Write down synthesis and chemical reaction of cycloalkane
M.M. COLLEGE OF PHARMACY
MAHARISHI MARKANDESHWAR (DEEMED TO BE
UNIVERSITY), MULLANA, AMBALA, HARYANA (India)133207
(Established under section 3 of UGC, act 1956)
(Accredited by NAAC with Grade ‘A++’)
Long type questions
Unit-I
1. What are aromatic compounds? Write down the criteria for aromaticity of any compounds with examples
2. What is electrophilic reaction of aromatics compounds? Write down mechanism of Friedel-Craft acylation and
alkylation of Benzene and their limitation.
Unit-II
1. What is the nature of Amine functional group? Classify the different types of amine and give suitable example. Why
aromatic amine is less basic than aliphatic amine?
2. Why phenol is acidic in nature? Write down the synthesis and chemical reaction of phenol derivatives
compounds.
Unit-III
1. What is saponification value? How to calculate saponification value and give its chemical reaction
2. What are fatty acids? Classify lipids and fatty acids with examples
Unit-IV
1. What is naphthanol? Write down different type and uses of naphthalnol compounds.
2. What is polynuclear hydrocarbon? Could you write down the classification and nomenclature of polynuclear hydrocarbon
(naphthalene and phenanthrene)?
Unit-V
1. What is cycloalkane? Write down nomenclature of cycloalkane of all single ring and double ring structure
(Bicyclo) with examples
2. What is Dieckmann reaction? Write down the synthesis of cyclopentane from diethyl adipate
