PHARMACEUTICAL ORGANIC CHEMISTRY-II (BP301T)

UNIT-I

1. Chloro group is
a. Electron withdrawing by resonance effect
b. Electron withdrawing by inductive effect
c. Electron withdrawing by both inductive and resonance effect
d. Electron donating by both inductive and resonance effect
Ans: b Electron withdrawing by inductive effect
2. Cyclopentadienyl cation is a
a. Aromatic
b. Non aromatic
c. Anti – aromatic compound
d. Heterocycle
Ans: c Anti-aromatic compound

3. Chemically DDT is
a. Dichlorodiphenyltrichloroethane
b. Dichloroethane
c. Trichloroethane
d. Dichloro propane
Ans: a Dichlorodiphenyltrichloroethane

4. Saccharine is used as
a. Preservative
b. artificial sweetener
c. flavouring agent
d. colouring agent
Ans: b Artificial sweetener

5. Catalyst used in Friedel-crafts alkylation is a

a. Ammonium chloride
b. Aluminium chloride
c. Calcium chloride
d. Sodium chloride
Ans: b Aluminium chloride

6. The example of strong electron withdrawing group is

a. Nitro group
b. Alohol
c. Ether
d. Amines
Ans: a Nitro group

7. Molecule must have _____ π electrons to be aromatic compound

a. 2n+2
 b. 4n+2
c. 6n+2
d. 8n+ 2
Ans: b 4n+2

8. The X-Ray diffraction studies of Benzene shown that the c-c bonds have a length of
a. 1.54 Å
b. 1.34 Å
c. 1.39 Å
d. 1.59 Å
Ans: c 1.39 Å

9. The carbons in benzene are ____ hybridized.

a. Sp2
b. Sp3
c. Sp
d. Sp2d
Ans: a Sp2

10. The electrophile accepts a pair of electrons from benzene to form a resonance
stabilized ______
a. Carbocation
b. Carbanion
c. Nitronium ion
d. Anilinium ion
Ans: a carbocation

11. Aldehyde is an example of

a. Electron withdrawing group
b. Electron donating group
c. Ortho directing group
d. Activating group
Ans: a Electron withdrawing group

12. ____ is used for the treatment of Scabies

a. Benzene Hexachloride
b. Saccharin
c. Chloramine
d. DDT
Ans: a Benzene Hexachloride

13. Mono substitution of Benzene produces ___ substituted product

a. 1
b. 2
c. 3
d. 4
Ans: a 1

14. Reaction of Benzene with Ferric chloride gives ____ Color

a. Purple
 b. Pink
c. Red
d. Yellow
Ans: a Purple.

15. The c-c bond angle in benzene is

a. 120°
b. 180°
c. 360°
d. 90°
Ans: a 120°

16. The amino group present in aniline will direct the second substituent to
a. Ortho and para
b. Para and meta
c. Meta and ortho
d. Meta
Ans: a Ortho and para

17. ____ is used as Antifouling agent

a. Chloramine T
b. BHC
c. Saccharin
d. Naphthol
Ans: a Chloramine T

18. The electrophile in Nitration reaction of Benzene is

a. NO2+
b. NH4+
c. NO3+
d. NH3+
Ans: a NO2+

19. Friedel craft alkylation _____ when used with strong deactivating groups.
a. Fails
b. Neutral
c. Activated
d. Rearranges
Ans: a Fails

20. Benzene reacts with acid chlorides in the presence of AlCl3 to give
a. Aromatic ketones
b. Aromatic amines
c. Aromatic acids
d. Aliphatic amines
Ans: a Aromatic ketones
 UNIT- 2
21. Hofmann degradation of amides gives a
a. Primary amine
b. Secondary amine
c. Tertiary amine
d. Quaternary amine
Ans: a Primary amines

22. Reimer Tiemann reaction is used to synthesize

a. Aldehydes
b. Esters
c. Acids
d. Amines
Ans: a Aldehydes

23. _____ reaction is used to synthesize aromatic acids from phenols

a. Kolbe
b. Reimer Teimann
c. Esterification
d. Hydrolysis
Ans: a Kolbe

24. ______ are acid strengthening agent.

a. Electron withdrawing group
b. Electron donating group
c. Ortho directing group
d. Activating group
Ans: a Electron withdrawing group

25. Dow’s process is used to synthesize ___

a. Phenol
b. Acid
c. Alcohol
d. Amines
Ans: a Phenol

26. Aromatic amines are synthesized from aryl halides by

a. Ammonolysis
b. Reduction
c. Nitration
d. Hydrolysis
Ans: a Ammonolysis

27. Electron donating group will

a. Increase the basicity of aromatic amines
b. Decrease the basicity of aromatic amines
c. Neutralize the basicity of aromatic amines
d. Increase the acidity of aromatic amines
Ans: a Increase the basicity of aromatic amines
28. Aromatic amines are
a. acidic in nature
b. basic in nature
c. neutral compounds
d. amphoteric compound
Ans: b Basic in nature

29. Reimer-Tiemann reaction is characteristic reaction for

a. Carboxylic acids
b. Amines
c. Phenols
d. Alcohols
Ans: c Phenols

30. The more acidic compound is ___

a. P-cresol
b. Phenol
c. P-chlorophenol
d. P-nitro phenol
Ans: P-nitro phenol

31. Reduction of Nitro compounds gives

a. Amines
b. Aldehydes
c. Ketones
d. Acid
Ans: a Amines

32. Aromatic amines turn to brown color because of

a. Oxidation
b. Reduction
c. Redox reaction
d. Halogenation
Ans: a Oxidation

33. The reaction of Aromatic amines with Aldehydes gives

a. Schiff base
b. Manich base
c. Aldehydes
d. Acid
Ans: a Schiff base

34. Benzoquinones are formed when aromatic amines undergoes

a. Oxidation
b. Reduction
c. Halogenation
d. Nitration
Ans: a Oxidation
35. Electron withdrawing group ___ the basicity of Aromatic amines
a. Increases
b. Decreases
c. Neutralizes
d. No reaction
Ans: b Decreases

36. The reaction used to synthesize aryl halides using diazonium salts is
a. Sandmeyer reaction
b. Kolbe reaction
c. Dow’s process
d. Reimer Teimann reaction
Ans: a Sandmeyer reaction

37. The process of converting amines into diazonium salt is

a. Diazotisation
b. Polymerisation
c. Vaporization
d. Sulphonation
Ans: a Diazotisation

38. The hydrolysis of Nitriles gives

a. Aromatic acid
b. Aromatic amines
c. Aromatic amides
d. Phenols
Ans: b Aromatic amines

39. Esters are formed by the reaction of Aromatic acid with

a. Alcohol
b. Acid
c. Amine
d. Amide
Ans: a Alcohol

40. The acidity of aromatic acids can be increased in the presence of

a. Electron withdrawing group
b. Electron donating group
c. Activating group
d. Ortho -para directors
Ans: a Electron withdrawing group

UNIT-III
41. Fats and oils are
a. Esters
b. Amides
c. Carboxylic acids
d. Phenol
Ans: a Esters
42. Alkaline hydrolysis of fats and oils is called
a. Saponification
b. Fermentation
c. Diazotisation
d. Rancidification
Ans: a Saponification

43. Acid value represents the amount of

a. Water in oil
b. Free fatty acids in oil
c. Soap in oil
d. Alkali in oil
Ans: b Free fatty acids in oil

44. A higher saponification value means

a. Higher molecular weight of fatty acids
b. Long chain fatty acids are present
c. Higher free fatty acid content
d. Lower molecular weight of fatty acids
Ans: d Lower molecular weight of fatty acids

45. Saponification value can be determined by titrating with

a. Sodium hydroxide
b. Acetic acid
c. Ethanol
d. Hydrochloric acid
Ans: d Hydrochloric acid

46. Acid value is an important parameter for

a. Determining the quality of edible oils
b. Assessing the color of oils
c. Measuring the molecular weight of fats
d. Identifying the presence of antioxidants
Ans: a Determining the quality of edible oils

47. The Reichert-Meissl (RM) value is used to measure

a. The amount of volatile free fatty acids
b. The total fatty acid content
c. Degree of unsaturation
d. The iodine content of oils
Ans: a The amount of volatile free fatty acids

48. The iodine value of a fat gives information about

a. Its saponification number
b. Its iodine content
c. The degree of unsaturation of its fatty acids
d. The presence of acetyl groups
Ans: c The degree of unsaturation of its fatty acids

49. The iodine value is typically expressed in

 a. Grams of iodine per 100 grams of fat
b. Milligrams of KOH per gram of fat
c. Grams of free fatty acid per 100 grams of fat
d. Milligrams of soap per gram of fat
Ans: a Grams of iodine per 100g of fat

50. Acetyl value is used to determine

a. The free fatty acid content
b. The free hydroxy group of fatty acids
c. The presence of unsaturated fatty acids
d. The molecular weight of glycerides
Ans: b The free hydroxy group of fatty acids

51. Saponification value is significant because it measures

a. The amount of alkali needed to saponify a fat
b. The degree of unsaturation in fats
c. The molecular weight of fatty acids
d. The total free fatty acids in a fat
Ans: a The amount of alkali needed to saponify a fat

52. Short-chain fatty acids contain________carbon atoms.

a. 2-5
b. 6-12
c. 13-21
d. More than 22
Ans: a 2-5

53. Polyunsaturated fatty acids contain

a. One double bond
b. Two or more double bonds
c. No double bonds
d. Branched chains
Ans: a One double bond

54. Fats and oils are primarily composed of

a. Glycerol and Fatty acids
b. Carbohydrates
c. Proteins
d. Nucleotides
Ans: a Glycerol and Fatty acids

55. Saturated fatty acids are generally solid at room temperature because
a. They have no double bonds, allowing them to pack tightly
b. They are branched-chain fatty acids
c. They have more carbon atoms
d. They contain more unsaturation
Ans: a They have no double bonds, allowing them to pack tightly

56. Fatty acids with even numbers of carbon atoms are primarily produced through
a. The beta-oxidation pathway
 b. The biosynthesis of fatty acids
c. The breakdown of glucose
d. The digestion of triglycerides
Ans: b The biosynthesis of fatty acids

57. Fats are typically _______ at room temperature, while oils are _______ at room
temperature
a. Solid, solid
b. Solid, liquid
c. Liquid, solid
d. Liquid, liquid
Ans: b Solid, liquid

58. The primary difference between fats and oils is their

a. Source
b. Chemical structure
c. Degree of unsaturation
d. Melting point
Ans: c Degree of Unsaturation

59. Fats are usually derived from

a. Plant sources
b. Animal sources
c. Plant and animal sources
d. Only synthetic sources
Ans: b Animal sources

60. The melting point of fats is generally _______ than oils.

a. High
b. Low
c. Neutral
d. Equal
Ans: a High

UNIT IV

61. The Molecular formula of Naphthalene is

a. C10H8
b. C8H6
c. C10H6
d. C10H14
Ans: a C10H8

62. The compounds in which 2 or more carbon atoms are shared in common by two or
more aromatic rings are
a. Fused ring polynuclear hydrocarbons
b. Isolated ring polynuclear hydrocarbons
c. Aliphatic acids
d. Aliphatic amines
Ans: a Fused ring polynuclear hydrocarbons
63. Tetralin is an intermediate in the synthesis of
a. Naphthalene
b. Anthracene
c. Phenanthrene
d. Diphenyl methane
Ans: a Naphthalene

64. The reaction of Naphthalene with Nitric acid gives

a. 1-Nitro Naphthalene
b. 2-Nitro Naphthalene
c. 7-Nitro Naphthalene
d. 6-Nitro naphthalene
Ans: a 1-Nitro Naphthalene

65. Phthalic anhydride is produced by the ____ of Naphthalene

a. Reduction
b. Oxidation
c. Nitration
d. Redox
Ans: b Oxidation

66. ______ is used to prevent Moths in Clothes

a. Naphthalene
b. Anthracene
c. Phenanthrene
d. Diphenyl methane
Ans: a Naphthalene

67. Anthracene is the Polynuclear aromatic hydrocarbon having ___ benzene rings fused
together.
a. Two
b. Three
c. Four
d. Five
Ans: b Three

68. In Haworth synthesis of Anthracene, Benzene reacts with _____ to give the product.
a. Aniline
b. Benzoic acid
c. Benzanilide
d. Phthalic anhydride
Ans: d Phthalic anhydride

69. Phenanthrene is the isomer of ____ with molecular formula C14H10

a. Anthracene
b. Diphenyl methane
c. Triphenyl methane
d. Naphthalene
Ans: a Anthracene
70. The oxidation of Phenanthrene produces
a. Phthalic acid
b. Diphenic acid
c. Benzoic acid
d. P-Amino benzoic acid
Ans: b Diphenic acid

71. The catalyst used in clemmensen reduction is

a. AlCl3
b. Zn/Hg
c. Ni
d. Pd
Ans: b Zn/Hg

72. Benzene reacts with ____ to form anthracene

a. 1,2,3,4 tetrabromoethane
b. 1,1,2,2, tetrabromoethane
c. 1,2,3,4 tetrabromo Methane
d. 1,1,2,2, tetrabromo Methane
Ans: b 1,1,2,2 Tetra bromo ethane

73. Diphenyl methane is produced by ____ of Benzophenone

a. Friedel craft acylation
b. Friedel craft alkylation
c. Clemmensen reduction
d. Aromatisation
Ans: c Clemmensen reduction

74. The reaction of 2 molecules of Benzene with benzaldehyde gives

a. Diphenyl methane
b. Triphenyl methane
c. Diphenyl ethane
d. Naphthalene
Ans: b Triphenyl methane

75. The oxidation of anthracene gives

a. Anthraquinol
b. Alizarin
c. Anthraquinone
d. Nitro anthracene
Ans: c Anthraquinone

76. The molecular formula of Diphenyl methane is

a. C6H5CH3
b. C13H12
c. C14H10
d. C12H10
Ans: b C13H12
77. Triphenylmethane contains:
a. Three phenyl groups and one CH group
b. Two phenyl groups and one methyl group
c. Three phenyl groups and one carbonyl group
d. One phenyl group and two methyl groups
Ans: a Three phenyl groups and one CH group

78. The molecular formula of Triphenylmethane is:

a. C6H5CH3
b. C14H12
c. C19H16
d. C18H14
Ans: c C19H16

79. The reaction of Diphenylmethane with bromine gives

a. Benzyl bromide
b. 1,2-Dibromodiphenylmethane
c. Triphenylmethane
d. 1,1-Dibromodiphenylmethane
Ans: d 1,1-Dibromo diphenyl methane

80. In the production of dyes, Diphenylmethane is used as

a. A catalyst in reactions
b. A precursor in dye synthesis -
c. A stabilizer in dye formulations
d. A solvent for colorants
Ans: b A precursor in dye synthesis

UNIT -V

81. Cycloalkanes are hydrocarbons with

a. A single carbon-carbon double bond
b. A ring structure containing only single bonds
c. A benzene ring
d. One or more carbon-carbon triple bonds
Ans: b A ring structure containing only single bonds

82. The general formula for cycloalkanes is

a. CnH2n
b. CnH2n+2
c. CnH2n-2
d. CnH2n+1
Ans: a CnH2n

83. The simplest cycloalkane is

a. Cyclohexane
b. Cyclopropane
c. Cyclobutane
 d. Cyclopentane
Ans: b Cyclopropane

84. The strain in cycloalkanes due to bond angles is called

a. Torsional strain
b. Angle strain
c. Steric strain
d. Hyperconjugation
Ans: b Angle strain

85. Cyclopropane is more reactive than cyclohexane due to

a. Less bond strain
b. Its high torsional strain
c. Its high angle strain
d. The presence of a double bond
Ans: c Its high angle strain

86. The preferred conformation of cyclohexane is

a. Boat
b. Chair
c. Twisted boat
d. Half chair
Ans: b Chair

87. Cycloalkanes with five carbon atoms are called

a. Cyclopropane
b. Cyclopentane
c. Cyclohexane
d. Cycloheptane
Ans: b Cyclopentane

88. Cycloalkanes with larger ring sizes are more stable than smaller ones like
cyclopropane because
a. They have more angle strain
b. They have less torsional strain
c. Their rings are less strained
d. Their rings have more flexibility
Ans: c Their rings are less strained

89. In the chair conformation of cyclohexane, the axial hydrogens are

a. Parallel to the ring
b. Perpendicular to the ring
c. Opposite to the equatorial hydrogens
d. In the plane of the ring
Ans: b Perpendicular to the ring

90. The angle strain in cyclopropane arises because

a. The bond angles are 60°, which is far from the ideal tetrahedral angle of
109.5°
b. The bonds are strained due to electron repulsion
 c. The carbon atoms are forced into a linear arrangement
d. The structure is symmetrical and balanced
Ans: a The bond angles are 60°, which is far from the ideal tetrahedral angle of 109.5°

91. In cyclobutane, the bond angles are approximately

a. 90°
b. 120°
c. 180°
d. 360°
Ans: a 90°

92. The stability of cycloalkanes increases with

a. A larger ring size
b. A smaller ring size
c. Increased angle strain
d. More torsional strain
Ans: a A larger ring size

93. In cyclohexane, equatorial substituents are more stable than axial substituents because
a. They experience less steric hindrance
b. They are closer to other substituents
c. They are at a higher energy state
d. They are more electron-rich
Ans: a They experience less steric hindrance

94. Coulson-Moffitt theory was developed to explain the instability of

a. Alkanes
b. Alkenes
c. Cycloalkanes
d. Aromatic compounds
Ans: c Cycloalkanes

95. Baeyer strain theory suggests that the strain in cycloalkanes arises when
a. The molecule is too large
b. The bond angles deviate significantly from the ideal tetrahedral angle
c. There is conjugation in the molecule
d. There is excessive electron repulsion between bonds
Ans: b The bond angles deviate significantly from the ideal tetrahedral angle

96. According to the Strainless Ring Theory, cyclohexane is stable because

a. It adopts a conformation that reduces strain
b. It has a large ring size
c. Its bonds are all in perfect alignment
d. It is highly conjugated
Ans: a It adopts a conformation that reduces strain

97. A banana bond is a type of bond found in

a. Cyclopropane
b. Cyclopentane
c. Cyclohexane
 d. Cycloheptane
Ans: a Cyclopropane

98. The ideal bond angle in a tetrahedral geometry is

a. 90°
b. 109.5°
c. 120°
d. 180°
Ans: b 109.5°

99. In Internal wurtz's reaction _____ is treated with zinc in the presence of hydrochloric
acid
a. Alkyl halides
b. Cycloalkyl halides
c. Aryl halides
d. Alkynes
Ans: a Alkyl halides

100. The calcium or barium salts of dicarboxylic acid are used in ___ method of
Preparation of cycloalkanes
a. Internal wurtz reaction
b. Ruzicka reaction
c. Dieckmann reaction
d. Diels alder reaction
Ans: b Ruzicka’s reaction