Meningitis
Meningitis is an inflammation of the fluid and membranes
(meninges) that covers brain and spinal cord.
The most common causes of meningitis are viral and bacterial or
fungi infections transported through blood stream or from
nasopharynx or respiratory Tracts , sinusitis , otitis media
Viral meningitis most common than bacterial
Bacterial meningitis Less common but high mortality.
Meningitis can be classified as acute or chronic, depending on onset of
symptoms.
a.    Acute meningitis—onset within hours to days.
b.    Chronic meningitis—onset within weeks to months
Acute bacterial meningitis causes
      Streptococcus pneumonia most common in adults
      Homophlus influenza
      Neisseria meningitides
      Staphylococcus aureus
      Streptococcus group B Common in pediatrics
Clinical features
Symptoms (any of the following may be present)
      a.     Headache (may be more severe when lying down)
      b.     Fevers
      c.     Nausea and vomiting
      d.     Stiff, painful neck
        e.       Malaise
        f.       Photophobia
        g.       Alteration in mental status (confusion, lethargy, even coma)
Signs
              Neck stiffness
              Meningeal rash
              Increase intracranial pressure (papilledema)
              Kernig sign—inability to fully extend knees when patient is
               supine with hips flexed
              Brudzinski's sign (passive flexion of the neck causes flexion
               of the thighs and knees).
Diagnosis
1. CSF (cerebrospinal fluid ) examination (LP) ) lumbar puncture )
Bacterial meningitis—pyogenic inflammatory response in CSF.
        Elevated WBC count—PMNs predominate.
        Low glucose.
        High protein.
        Gram stain—positive in 75% to 80%
Aseptic meningitis— (viral meningitis) no pyogenic inflammatory
response in CSF.
        There is an increase in mononuclear cells. Typically a lymphocytic
        pleocytosis is present.
        Protein is normal or slightly elevated.
        Glucose is usually normal.
        CSF may be completely normal.
2. CT Scan
3. Blood culture
Treatment
   1. Bacterial meningitis
          Empirical Antibiotics therapy immediately
             Cefotaxime + ampicillin + vancomycin
          Aminoglycoside if less than 4 week
          Intravenous antibiotic
          Analgesic and
             antipyretic
          Steroid
          Vaccination
          Prophylaxis )rifampin or
             ceftriaxone (
   2. Viral meningitis
       Supportive care only
       Analgesic and antipyretic
         drugs
Complication of bacterial meningitis
            Seizures
            Brain abscess
            Coma
            Deafness
            Brain damage