SUPPOSITORY MEDICATION  Candida (Monilia) albicans

- Solid dosage forms intended for insertion into body Systemic Action
orifices where they melt, soften, or dissolve and exert
local or systemic effects. - Mucous membranes of the rectum and vagina permit
- Commonly used rectally and vaginally and the absorption of many soluble drugs.
occasionally urethral. - Rectum is frequently used
- Has various shapes and weights. - Vagina is not frequently used for systemic action
- Among the advantages over oral therapy of the rectal
Different types of suppositories route of administration for achieving systemic effects:
1. Drugs destroyed or inactivated by the pH or
1. Rectal suppository
enzymatic activity of the stomach or intestines
2. Vaginal suppository
need not be exposed to this destructive
3. Urethral suppository
environment.
2. Drugs irritating to the stomach may be given w/o
causing such irritation.
3. Drugs destroyed by portal circulation may bypass
the liver after rectal absorption.
- Examples of drugs administered rectally in the form
of suppositories for their systemic effect:
1. Prochlorperazine
o Anti – sickness medicine.
o Help stop feeling or being sick
Different shapes of suppositories  Nausea or vomiting
2. Paracetamol
o To relieve pain and a high temp. in children
who find it difficult to swallow tablets or
syrup, or who are being sick a lot.
3. Indomethacin
o Non – steroidal anti-inflammatory drug
(NSAID)
o Help relieve symptoms of moderate to severe
arthritis.
4. Dulcolax
o Used to treat constipation

CONTRAINDICATIONS
Local Action 1. Rectal bleeding
2. Diarrhea
- Rectal suppositories 3. Recent Prostate or Rectal Surgery
o Intended for localized action 4. Local trauma
o Frequently used to relieve: 5. Undiagnosed GI disturbances
 Constipation 6. Cardiac Arrythmia’s
 Pain
 Irritation
 Itching
 Inflammation
o Associated with hemorrhoids or other
anorectal conditions.
o Glycerin suppositories
 Laxative
 Promotes laxation by the local
irritation of the mucous membranes.
- Vaginal suppositories
o Intended for localized effects
 Contraceptives
 Antiseptics in feminine hygiene
 Specific agents to combat as
invading pathogens
o Nonoxynol – 9
 Contraception
o Trichomonacides
 Vaginitis
 Trichomonas vaginalis