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Gentamicin and Co Trimoxazol

The document compares the pharmacokinetics of gentamicin and co-trimoxazole. It discusses their administration routes, distribution, absorption, metabolism, elimination and half-lives. It also lists some of their drug interactions such as with acyclovir, aminoglycoside drugs, acetylsalicylic acid, diabetes medications, and heparin.

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helianthusannus1997
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33 views2 pages

Gentamicin and Co Trimoxazol

The document compares the pharmacokinetics of gentamicin and co-trimoxazole. It discusses their administration routes, distribution, absorption, metabolism, elimination and half-lives. It also lists some of their drug interactions such as with acyclovir, aminoglycoside drugs, acetylsalicylic acid, diabetes medications, and heparin.

Uploaded by

helianthusannus1997
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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Download as PDF, TXT or read online on Scribd
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EZZAHRAOUI HAJAR

GROUP 10601FA

Pharmacokinetic
Gentamicin Co-trimoxazole
Administration route IV or IM Oral tablet, IV, suspension
(topical forms are also ( pediatric use)
available)

Distribution Small Volume of distribution Well distributed into body


( stays primarily in the tissues, including the lungs,
extracellular fluid) kidneys, prostate and middle
ear.

Absorption Well absorbed in body fluids Well absorbed from the GIT.
Metabolism Does not undergo significant Hepatic metabolism
metabolism in the body Acetylation gluconasation
Elimination Occurs primarily through the Primarily excreted through the
kidneys, filtered by the kidneys.
glomerulus and undergoes
limited reabsorption.

Half life 2 -3 hours. Longer half life

Protein biding 30% low binding with albumin 70% high binding with
that make gentamicin more albumin
toxic than co-trimoxazole can not prescribed with (
heparin , warfarin , antidiabetic
drugs, ace drugs)

Drugs interaction
Gentamicin Co-trimoxazole
Acyclovir Acyclovir may decrease the Acyclovir may decrease the excretion
excretion rate of Gentamicin which rate of Trimethoprim which could result
could result in a higher serum level. in a higher serum level.
PHARMACOKINETIC
PHARMACOKINETIC
Aminoglycoside Gentamicin may decrease the excretion Trimethoprim may decrease the
rate of Streptomycin which could result excretion rate of Streptomycin which
drugs in a higher serum level. could result in a higher serum level.

PHARMACOKINETIC PHARMACOKINETIC
EZZAHRAOUI HAJAR
GROUP 10601FA

Acetylsalicylic acid Acetylsalicylic acid may decrease the The risk or severity of hypoglycemia can
excretion rate of Gentamicin which be increased when Acetylsalicylic acid is
could result in a higher serum level. combined with Sulfamethoxazole.
Phamacokinetic ( distribution state )
Pharmacokinetic
Diabetes type 2 The risk or severity of hypoglycemia The risk or severity of hypoglycemia
drugs can be increased when. can be increased when
(exp Dapagliflozin) pharmacokinetic pharmacokinetic

Heparin The therapeutic efficacy of The risk or severity of hyperkalemia


Gentamicin can be decreased when can be increased when
used in combination with Heparin.. Sulfamethoxazole is combined with
Heparin.
pharmacokenetic
PHARMACODYNAMIC Pharmacokenetic
PHARMACODYNAMIC

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