Urology Part 1
Urology Part 1
(PART I)
KATHLEEN R. GONZALES, MD, FPUA
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ANATOMY
* Anatomic structures: J)
IS : - Diaphragm
Kidneys 7 I Oveophacue
Left adrenal
Adrenals (suprarenal) gland
Left renal vein
Prostate " ——
Left ureter
Uterus (female)
Seminal vesicles Left ovary (female}
Urinary bladder
Urethra
—— Prostate (male)
[S
ituated mainly outside the peritoneum
Kathleen Gonzales MD ll — + B\
INTRAPERITONEUM AND RETROPERITONEAL ORGANS
and Retroperitoneal Organs - 4
kidneys
Kathleen Gonzales MD
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ANATOMY
KIDNEY AND ADRENAL
* The collecting system of the kidney is
composed of several major and minor calyces Right ho Left Kidney
that coalesce to form the renal pelvis renal artery — renal
* Renal pelvis tapers into UPJ where it joins the ry
ureter la —< Wey ~~ o
* Adrenal glands lie superomedially to the | = NA re
kidneys within Gerota’s fascia
* In the presence of a tumor or inflammatory renal veins
process, the adrenal can be very adherent to
ANATOMY
URETER
® Muscular structures that course anterior to the psoas
muscles from the renal pelvis to the bladder
® Blood supply
* Proximal ureter
— from aorta and renal artery (medial)
* Below the iliac vessels — from iliac arteries (lateral)
* Ureters course along the pelvic side wall and pass
under the uterine arteries in women (water under the
bridge) —prone to injury during hysterectomy
ANATOMY
BLADDER
* UB situated in the retropubic space in an
extraperitoneal position
* A portion of bladder dome is adjacent to the
peritoneum, so ruptures in this point can result in Urothalium
Lamina propria
intraperitoneal urine leakage
|
FEMALE
Kathleen Gonzales MD
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ANATOMY
BLADDER
* The sigmoid colon lies superolaterally and
may become adherent or fistulize secondary
to diverticulitis
* Rectum lies posterior to the bladder in males,
vagina and uterus in females
Kathleen Gonzales MD
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ANATOMY
PROSTATE
* Prostate is in continuity with the bladder neck, and the
urethra courses through it
® Significant smooth muscle component and can provide
urinary continence even in the absence of the external
striated sphincter
* Puboprostatic ligament — connect the prostate to the
pubic symphysis so pelvic fractures often result in
proximal urethral injuries
* Denonvillier's fascia — between prostate and rectum,
the main anatomic barrier that prevents prostate cancer
from regularly penetrating the rectum
ANATOMY
PENIS
* Composed of three main bodies: pair of corpus
cavernosum and corpus spongiosum
® Corpus cavernosum- paired, cylinder-like structures that
are the main erectile bodies of the penis
* Proximally, lie along the medial aspects of the inferior
pubic rami in the perineum
* Distally, they fuse along their medial aspects and form the
pendulous penis
* Consist of a tough outer layer called tunica albuginea
and spongy, sinusoidal tissue inside that fills with blood
during erection
* Have numerous vascular interconnections so they function
as one compartment
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ANATOMY
PENIS
® Caverosal arteries are branches of the penile artery
® Sinusoidal tissue is innervated by cavernosal nerves
(autonomic nerves from the hypogastric plexus)
* Corpus spongiosum — does not have the same
tunical layers as the corpora cavernosum
® Surrounds the urethra
* Does not exhibit same firmness during erection
® The tip of the penis (glans) is in continuity with the
corpus spongiosum
ANATOMY
PENIS
Dorsz v
erficial Dorsal
* Surrounding all 3 bodies are the outer dartos Deep Dorsal, Superhicial
fascia and the inner Buck's fascia Wy, - 2. Superficial (Dartos) fascia
* Cremasteric fascia 7
* Internal spermatic fascia \
d \ Meter
® Parietal
i and visceral
i tunica
: :
vaginali si — between which \ J {no
sen
hydrocoeles form Figure 5.7. Contributions of the anterior
abdominal wall to the coverings of the
N Tunica albuginea — outer layer of the testis scrotum, spermatic cord, and testis
Kathleen Gonzales MD
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ANATOMY
SCROTUM AND TESTES
* Visceral layer of tunica vaginalis is adherent to the
testis
* Inside the tunica albuginea are the seminiferous
tubules nerve lg —
blood vessels ———— -
spermatic cord
* Blood supply enters the testis at the superior pole vas deferens ——Sui |
by way of spermatic cord seminderous — EE
tubule
UROLOGIC MALIGNANCIES
BLADDER CANCER
* Most common form of bladder cancer in the
US is transitional cell carcinoma (TCC)
* Risk factors: tobacco use, occupational
exposure to carcinogens (automobile exhaust
or industrial solvents)
Other forms of bladder cancer:
* Squamous cell — from chronic irritation from
catheters, bladder stones, schistosomiasis
infection
* Adenocarcinoma — from urachal remnants or
bladder exstrophy
Kathleen Gonzales MD ll — +
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UROLOGIC MALIGNANCIES
BLADDER CANCER
® Categorized into invasive(muscle-invasive) and
noninvasive(superficial) Urinary Bladder
Pubic Bone
Kathleen Gonzales MD ll — +
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UROLOGIC MALIGNANCIES
BLADDER CANCER
* Approach for cystectomy is a lower midline
incision from the umbilicus to the pubic
symphysis
Ovaries
Neo) ( Rectum
* In men, cystoprostatectomy is done
Vagina
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RADICAL CYSTECTOMY
\=:¥) Bladder cancer treatment: Cystectomy
Kathleen Gonzales MD
BLADDER CANCER
® Complications of bladder cancer surgery
involve perforation during TURBT
lleus, bowel obstruction, intestinal
anastomotic leak, urine leak, or rectal injury
during cystectomy and urinary diversion
DVT is common due to advanced age,
proximity of the iliac veins to the resection and
lymph node dissection, and presence of
malignancy
Kathleen Gonzales MD ll — +
TESTICULAR CANCER
®* Most common solid malignancy in men ages 15 to
35 years of age
Major risk factor is cryptorchidism (undescended
testis)
Most neoplasms arise from the germ
cells(seminanomatous and nonseminomatous)
Nongerm cell tumors (Leydig and Sertoli cell
tumors) are rare and follow a more benign course
All solid testicular masses observed on PE
and documented on ultrasound are malignant
itil proven otherwise
Kathleen Gonzales MD ll — +
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UROLOGIC MALIGNANCIES :
TESTICULAR CANCER
* Initial studies must include tumor markers:
* AFP, B-HCG, LDH
UROLOGIC MALIGNANCIES
RENAL CANCER Table 40-1 Bosniak Renal Cyst Computed Tomography Classification
RENAL CANCER
® Most cases are sporadic, but many hereditary forms
have been described
* Von-Hippel-Lindau disease — clear cell RCC
* Birt-Hogg-Dube syndrome — chromophobe tumors
Kathleen Gonzales MD ll — +
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RENAL CANCER
® Surgical options: partial and radical nephrectomy
(laparoscopic or open)
Laparoscopic partial nephrec is performed only in
experienced hands
Ablative techniques : cryoablation and radiofrequency
— for small renal masses
Kathleen Gonzales MD ll — +
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RENAL CANCER
* Up to 10% of RCC invades the lumen of the renal vein
or vena cava
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UROLOGIC MALIGNANCIES
RENAL CANCER
® Complications: thrombus embolization to the pulmonary
artery
® Intraoperative transesophageal echocardiography to
monitor possible embolization
® If it occurs, sternotomy/C-P bypass with extraction of
thrombus may be life saving
Kathleen Gonzales MD Ng
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UROLOGIC MALIGNANCIES
RENAL CANCER
® Incisions used for nephrectomy:
* Flank incisions — over the 11%" or 12! ribs from the AAL to
the lateral border of the rectus muscle (does not enter the
peritoneum)
® Anterior subcostal — transperitoneal
* Thoracoabdominal — for large tumors esp on the right
where the liver makes the exposure difficult (over the 10"
rib, carried further posterior and anterior than flank
incision)
® Complications: bleeding, pneumothorax, splenic injury,
liver injury, pancreatic tail injury; partial nephrectomy :
jy added risk of delayed bleeding and urine leak
Kathleen GonzalesMD § — + A De
PROSTATE CANCER
Most common nonskin malignancy in men
Screening include annual DRE and PSA starting at
age 50
Those with African American descent or those with
family history of PCA should be screened starting at
age 45
Men with abnormal DRE or elevated PSA are
indicated to undergo prostate biopsy
Majority of pxs with PCA will not die of the disease by
10 to 15 years
Kathleen Gonzales MD ll — +
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UROLOGIC MALIGNANCIES
PROSTATE CANCER
®* PCAs graded according to the Gleason Gleason's Pattern
scoring system (a sum of 2 scores) Ros : 1. Seal] unlform
glands
Kathleen Gonzales MD Sg N
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UROLOGIC MALIGNANCIES
PROSTATE CANCER
* Treatment options: Bladder
hs
* Active surveillance al Sp
® Brachytherapy
* Radical prostatectomy
® External beam radiation
® Androgen deprivation therapy
* Chemotherapy — for metastatic castrate resistant proste
UROLOGIC MALIGNANCIES
PROSTATE CANCER
® Surgical approaches for radical prostatectomy
* Retropubic — lower midline incision from pubic
symphysis to approx 5 cm below umblicus;
peritoneum not entered
* Perineal — transverse incision between the
scrotum and anus; reduced blood loss and
faster convalescence but do not allow lymph
node dissection
: i Perineal A h
Robotic — has slowly replaced laparoscopic RetfpUblC Approach el
approach for prostatectomy
* Lymph nodes are removed between the
external iliac and obturator vessels bilaterally
Kathleen Gonzales MD ll — +
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UROLOGIC TRAUMA
Grade Injury Type Description
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UROLOGIC TRAUMA
KIDNEY i.—
The American Ass ciation for t f Trauma (AAST) rer yma grading system
2 Perinephric hematoma without obvious parenchymal | Generally managed conservatively in a stable patient
>I ¢m laceration into the cortex without involvement | Generally managed conservatively in a stable patient
(CT urogram)
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UROLOGIC TRAUMA
KIDNEY
® To rapidly assess the presence of 2 functional
kidneys and extent of injury, @ single-shot, 10- [rues vee se mene ws re
min IVP (2mL/kg contrast) is used
If IVP is abnormal or the hematoma is pulsatile,
renal exploration should be performed
In renal exploration, begin with controlling the
renal hilum
Complete exposure; all nonviable tissue must
be debrided; injured collecting system must be
repaired; stent or percutaneous drain should be
Kathleen Gonzales MD
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UROLOGIC TRAUMA
URETER
* The retroperitoneal location of the ureter
protects it from external trauma
* Retrograde pyelogram — most sensitive test
for ureteral injury; a stent can be placed if a Dist usarortaroeony :
partial transection is observed MIDDLE i
Direct ureterourelerostomy
Ls
UROLOGIC TRAUMA
URETER
* Low ureteral injuries (below the iliac vessels)
— ureteral reimplantation
Direct ureteroureterostomy fa)
MIDDLE yo
* For longer defects — Psoas hitch, Boari flap,
Direct ureteroureterostomy
Transureteroureterostomy
Nephropexy Reimplantation
Psoas hitch
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BLADDER
* Can occur from penetrating and blunt trauma
* Classified into intraperitoneal and
extraperitoneal injuries(more common)
* Injuries are often associated with pelvic
fractures
® Ssx: gross or microscopic hematuria, electrolyte
imbalance, azotemia, metabolic derangements,
leukocytosis (from urine absorption), fever,
~ prolonged ileus
Kathleen Gonzales MD ll — +
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BLADDER
* Diagnostics: fluoroscopic or CT cystogram
(300-400 mL); important to have a postdrainage
film to assess for persistent contrast
* Extraperitoneal injury — catheter drainage for 7
to 10 days (unless surgery is to be done for
pelvic fractures)
* Intraperitoneal injury — explored immediately
and repaired
“| © All should have cystogram prior to catheter
Jy. removal
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UROLOGIC TRAUMA
URETHRA
® Divided into anterior location (penile and bulbar) and
posterior (membranous and prostatic)
® Should be anticipated with pubic ramus fractures and
occur in 10% of unilateral and 20% of bilateral injuries
® Any patient with blunt pelvic trauma, blood per meatus,
hematuria, inability to void, perineal hematoma (should
consider urethral injury until proven otherwise)
* Diagnostics: Retrograde Urethrography (RUG)
® Partial or complete disruption can be diagnosed based
on extravasation or filling of the proximal urethra
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Kathleen Gonzales MD Ng A
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URETHRA
Partial urethral injuries — attempt at catheter
placement
Complete disruption — placement of suprapubic
tube, primary repair
Anterior injuries — related to blunt straddle
injuries and penetrating trauma
Management: catheter drainage; primary repair
for 1-2cm defect
Posterior injuries — from pelvic crush injuries
and shearing forces
Management: suprapubic tube, delayed repair
\ or delayed primary realignment *
Kathleen Gonzales MD ll — +
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URETHRA
Urethral strictures — trauma or
inflammatory process
Staged by either RUG or VCUG
Type of repair depends on location, length,
severity
Short defects — dilatation or cystoscopic
urethrotomy
Long defects — open repair, grafting”
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UROLOGIC TRAUMA
TESTES
®* Most commonly occurs with blunt injuries
with enough force to rupture the tunica
albuginea
* Ultrasound is the preferred imaging — to
evaluate testicular blood flow, presence of
testicular contusions, intratesticular aT ne:
hematoma, hematocoele or disrupted tunica Testicular rupture, before and after surgical debridement and
repair.
albuginea
Kathleen Gonzales MD
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UROLOGIC TRAUMA
TESTES
* Goal of surgery: salvage as much
parenchyma as possible; and avoid
Ischemic atrophy (from a large hematocele)
or abscess formation
® Aruptured tunica albuginea can be repaired
primarily and nonviable tissue debrided
* With major devascularization and nonviable Testicular rupture, before and after surgical debridement and
repair.
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UROLOGIC TRAUMA
PENIS
* Rare injuries that involve a traumatic rupture of the
tunica albuginea (usually during sexual intercourse)
* The engorged penile corporeal bodies can rupture if
sufficient force is generated against the partner’s
pubic symphysis or perineum
* May notice an immediate audible “pop” and
experience rapid detumescence; immediate swelling
* If Buck's fascia is disrupted, swelling and ecchymosis
throughoutthe perinuem (butterfly sign)
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Kathleen Gonzales MD — ag NS =
OU 01:31:29
PENIS
® Exploration by a circumcising incision and repair
of the defect offers the best chance to avoid
permanent ED and penile deformity
RUG to rule out urethral injury
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