Karthik Srinivasan Varma

Founder & CEO, SEBIPL

Investor : Novel technologies, Innovation & Startup
Mobile: +91-9176112188
Email: karthiksrinivasanvarma@gmail.com

Result-oriented professional with a proven record of achievement in conceiving & implementing effective ideas; targeting
mid/senior managerial level assignments in Business Development, Strategic Planning, DATA Analytics & Process
development with the extensive experience gained in Pharma and Bio Pharma Industry

Industry Preference: Bio-Pharamceutical/ Pharamceutical

Location Preference: India /Overseas

PROFILE SUMMARY
 A competent professional with 20 years of rich experience in the field of Bio-Pharamceutical/ Pharamceuticals
 Extensive experience in working with GLP, GMP practice multi-nationals in a range of Microbiology Diagnostic,
Biotechnology R&D and Quality Control in Vaccine manufacturing companies
 Expertise in undertaking RCA, CA / PA initiates & closing of NCs, executing internal and external audit compliance; skilled
in working on analytical instruments and equipment
 Gained exposure in interfacing with WHO PQ, Several Foreign NRA & CDCSO Audits Fast and effective learner
 Enterprising leader with a strong record of contributions that invigorated processes / products, heightened productivity &
enhanced internal controls:
 Planning day-to-day research activities and resolving procedural problems for timely completion of objectives; setting up,
calibrating, operating & maintaining a variety of laboratory equipment as specified by the requirements of study
 Applying QA & QC tools / approaches to analytical processes within the business unit; formulating & maintaining research
objectives complementary to policies
 A forward thinking person with strong communication, analytical & organizational skills; well organized with a track
record that demonstrates self-motivation & creativity to achieve corporate & personal goals

CORE COMPETENCIES
Quality Assurance & Control ISO Management System Organizational Structure Designing
Change Management Research & Development Experiments & Scientific Findings
Training & Development Root Cause Analysis & Resolution Team Building & Leadership

ORGANISATIONAL EXPERIENCE
Mar 17 – Present SAAI Electro Biogenic India Pvt Ltd, Chennai as CEO
Jun’15 –Mar 2017 Green Signal Bio Pharma Pvt. Ltd., Chennai as Manager & Head – QC
Sep’09- Jun’14 HLL Ltd.
Deputation / Growth Path:
HLL Lifecare Ltd., Chennai as Senior Research Fellow Sep’09 - Dec’12
HLL Biotech Ltd., City as Senior Research Associate Jan’13 - Jun’15
Jul’07 – Sep’09 ABL Biotechnologies Ltd., Chennai as Technical Associate
Jul’06 -Jun’07 Phoenix Industries, Malaysia as QC Supervisor
Jul’04 – Jun’06 Ranga Nursing Home, Chennai as Microbiologist
Key Result Areas:

Business Development / Strategic Planning

 Responsible for providing strategic leadership for the company by working with the board of directors and the executive
management team to establish long-range goals, strategies, plans and policies and develop high quality business strategies
and plans ensuring their alignment with short-term and long-term objectives,
 Lead and motivate subordinates to advance employee engagement develop a high performing managerial team, Oversee
all operations and business activities to ensure they produce the desired results and are consistent with the overall
strategy and mission, Make high-quality investing decisions to advance the business and increase profits Enforce
adherence to legal guidelines and in-house policies to maintain the company’s legality and business ethics
 Review financial and non-financial reports to devise solutions or improvements, Build trust relations with key partners
and stakeholders and act as a point of contact for important shareholders, Analyze problematic situations and occurrences
and provide solutions to ensure company survival and growth, Maintain a deep knowledge of the markets and industry of
the company

Quality Assurance & Control

 Updating the support documents during process and deviations; preparing SOPS in accordance to C-GMP; ensuring
process validation for IQ, OQ & PQ for qualification of instruments; undertaking DSIR, DBT, SIBRI, WHO audits and DCGI
Audits; preparing reports and memos for submission to ISO, FDA & other authorities
 Developing quality control test for identification using Reverse Transcriptase PCR technique for viral vaccine products;
identifying and quantifying Bacterial contamination present In Quality Control sample by using Real Time PCR techniques

System Operations / Troubleshooting

 Managing small scale filtration systems like TFF, Homogenizer, Chromatography and setting up of Downstream
Purifications Systems; operating Ion Exchange Chromatography by using Millipore K-prime III chromatography system,
Ultra Filtration system and Ultracentrifuges and Liquid chromatography system by using HPLC System and AKTA
Explorer and GAS chromatography system using GC for analysis of fatty acids
 Executing operations pertaining to Gel filtration chromatography system by using Preparative Chromatography System
and AKTA Explorer; undertaking QC testing of the final product like, sterility, protein estimation, DNA contamination &
Protein purity SDS PAGE

Experiments & Equipment Design / Scientific Discussions

 Designing experiments and preparing protocols for execution based on the objectives; designing equipment and facility
requirements as per process and product requirement based on the objectives and regulatory requirements to be met
 Engaging in scientific discussions with clients, presenting the data generated and drawing conclusions; providing scientific
and technical support to junior team members through guidance, demonstrations and interactions on Wet lab

Team Management /Process Development

 Leading the technical team to provide process support during the research and development and process development
activities; managing key stakeholders; imparting assistance in lab scale process development & optimization of Human
Anti- Rabies Vaccine; reviewing documents and datasheets to ensure GMP, GLP compliance
 Monitoring the overall functioning of processes, identifying improvement areas and implementing adequate measures to
streamline the process flow; conducting internal process audits & process reviews for ensuring strict adherence to the
process parameters/systems as per defined guidelines

Accomplishments:
 Key team player in setting up and commissioning of process development lab as per process requirements for IVC
 Imparted pilot scale operation support and led a team of 4 people effectively which resulted into successful
demonstration of process for production of DHA for 8 consecutive and successful batches; purification, paving way for
enhanced of our patent filed with EU with confidence
 Conducted research and process development of DHA & Antiviral drugs from Marine fungi
 Undertook microbiological research, testing and process development for Viral Vaccine
 Ensured quality control and validation of process development and production of Antimicrobial and termed resistant
processed wood
 Received President Award, 1996 in Scouting for Service & General Proficiency
 Strain Isolation, characterization and improvement for development of indigenous polysaccharide and conjugate vaccine
for Haemophilus Influenzae B
 Implemented several attempts to identify & isolate Haemophilus influenza b and achieve Indigenous Hib Vaccine
 Recognized for increasing in-process capability by implementing QAP and appreciated for the same
 Pivotal in streamlining processes through measures such as IQC, QAP, GAP analysis, Personnel training and development

Projects Handled:
 QC Testing Method Development and Optimizations for BCG, Hep B, HiB, and Multivalent(penta) vaccine
 Strain Identification and Characterization for development of Hib conjugate vaccine (PRP-TT).
 QC Testing and Process Development for Purification of Hepatitis –B surface Antigen
 Strain Development, Media Optimization and Process Development in Schizochytrium for Production of DHA & EPA
 Development of Novel Drug Delivery System using Liposomal Drug Delivery System
 Development of PCR based RFLP method for Rapid Detection of Mycobacterium Tuberculosis
 Strain Development and Process Development and Optimization for Production of Phycocyanin and Phycoerythrin from
Dunaliella
 Quality Control Test for Viral & Bacterial Vaccine

PART TIME EXPERIENCE

May’02 -Jun’04 Ranga Nursing Home, Chennai as Microbiologist

EDUCATION
Pursuing Ph.D. Biotechnology (Dept. of Biotechnology) from University of Madras
2004 M.Sc. Biotechnology from Jaya College of Arts & Science, University of Madras
2004 PGDIM from Loyola College, University Of Madras
2002 B.Sc. Microbiology from Jaya College of Arts & Science, University Of Madras
2005 PGDCA from Bharath Computer Technology

DISSERTATION
 M.Sc.- “PCR Based Technique for Rapid Detection of rpoB Gene from Clinical isolates of Mycobacterium Tuberculosis”
 B.Sc. - “Design of Indigenous and Cost Effective Effluent Treatment Plant for Bio-Pharmaceutical Industries”

TRAININGS
 Lean Six Sigma Black Belt 2020
 Isolation and Characterization of Haemophilus Influenza Type B and differentiation form other strains at WHO Reference
Laboratory, Clinical Microbiology Department of CMC, Vellore Feb 2014
 Training on Quality Management Systems based on ISO 9001:2008 certifications June 2013 at BUREAU VERITAS, Chennai
 Biopharm Process Solutions Filtration School -Downstream Process in Biotechnology Application on Dec – 2011 at Merck
Millipore
 DNA Extraction and PCR Amplification of bacterial and plasmid DNA on Sep’10 at Satchika Biotech
 Application of RT_PCR and Microarray in Microbiology on Aug 2003 at VRF – Sankara Nethralaya& IAMM
 CME ON CURRENT TOPICS OF RELEVANCE IN MICROBIOLOGY on Sep-2003 at IAMM & ICVR –MMM
 State Level Workshop on Instrumental Techniques in Biotechnology on Jan -2003 at DG Vaishnava College

PAPER PUBLICATIONS
 A multiplex PCR kit for the detection of three major virulent genes in Enterococcus faecalis
B Meena, L Anburajan, KS Varma, NV Vinithkumar, R Kirubagaran, ... Journal of Microbiological Methods 177, 106061
 PCR Based Technique for Rapid Detection of rpoB gene from Mycobacterium tuberculosis. Indo – Australian Conference
on Bio Technology in Medicine Feb – 9th to 11th 2004
 Design of indigenous and cost effective Effluent Treatment Plant for Bio-Pharmaceutical industries “Jan 2002. (Jaya
Collage)
 LEEUWENHOEK ROLLING TROPHY Debate on Human Cloning – Ethical Concern Jan 2001 Microbiology Association (New
College). MICROQUEST -2000 Graphical Mute and Poster Presentation on Rangarajan Kumaramagalam Septicemia, Oct-
2000, Alpha College

IT SKILLS
 OS: Win 11 Mac OS High Sierra
 MS Office: Word, Excel and PowerPoint
 Adobe: PageMaker
 SAP (B1)
PERSONAL DETAILS
Date of Birth: 26th July 1981
Languages Known: English (IELTS), French, Malay, Hindi, Malayalam, Kannada, Telugu, Tamil, Bengali (Beginner)
Mailing Address: Plot No. 41 B, S 2 2nd floor , Binny Nagar Main Road, Kodungaiyur Chennai - 600051
Passport No.: J9432650
Driving License: F/TN/002/01/3899/2007 LMV -1805/2007/TN002 INDIA
Marital Status: Married
No. of Dependents: 2 Two (Wife & Son)
Nationality: Indian
Visa H1B valid Through 2027