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control valve transfer function and bioreactor
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Variable capacitance differential pressure
transducer
The variable capacitance differential pressure transducer is a very
popular device which is used to sense and transmit pressure differences.
Figure 114.2 shows a schematic of such a device. A pressure signal is
© scanned with OKEN Scannercoup 11 Dyramc Behave! Second cdr Systems 209
transferred through an isolating diaphragm and fill liquid in a
taney system with difleenia pressure sensing semen (rigoe
aria) attached atthe other end ofthe capillary (Figure 118.20). Here
ihe pressure is transmitted through a second isolating diaphragm and
fil Aguid Gilicone oil), to a sensing diaphragm. A reference pressure
Mil balance the sensing diaphragm on the other side ofthis diaphragm.
‘The position of the sensing diaphragm is detected by capacitor plates on
both sides of the diaphragm. A change in pressure ps of a processing
nit (€8. @ change in the pressure of a vessel, or a change in the liquid
Jove n'a tank, etc.) will make the pressure p change atthe end of the
capillary tube.
’A farce balance around the capillary will yield
force due to the force due to the
pressure p, of the process pressure p2 exercised
exercised attheend1 —] ~ at the end 2 of the
of the capillary capillary
= (mass) x (acceleration)
or
pid = pd (Me) (as)
a)
where A = cross-sectional area of the capillary
‘LZ length of the capillary tube
‘pz density of the liquid in the capillary tbe
{fThuia displacement in the capillary tube
= displacement of diaphragm
“The force pa at the end of the capillary is balanced by two forces:
/- resistance exerted by
mae ( tre iaphragm | +(
whic acts like a spring/
viscous ction fore)
MALO
Mreeised by he nia) AN?
ax
= kero
at
where K = Hooke's constant for the diaphragm
CZ dsnping coefficient of the viscous liquid in front of the
siaphragm
Substitute psd ine. (1A) by itseaua given bY caution (114.10) and
dbp) dx Ca, x aA py quaay
Kg.) dt? K dt x? y
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9 ponder sma
2
y indicates thatthe response Of the devicy
1A.) clearly a follows second-order dynamicg He,
Ite define t= ALP/Ke., 26r 0 it)
on (
the diaphragm displaces,
pangs oes ESSE Pi
TK,
nd A= UK, we take the transfer function ,
3 fs
6) Poe ers + 1
Pneumatic valve
‘The pacumatic valve isthe most commonly used final contol ele.
‘ent. Is system that ex
is inherent second-order dynamics,
Consider a typical pneumatic valve like that of Figure I1A.3, The
poston ofthe sem (or, equivalently, ofthe plug atthe end ofthe stem)
willdetermine the sizeof the opening
of the flow (flow rate). The position
‘lance of all forces acting on it. These forces are:
‘4 =Torce exerted by the compressed air at the top of the dia
Pree: 2 ag af the signal that opens or closes the
valve and 4 is the area of force acts
el the diaphragm; this force act
fore exerted
iaphragm;
the displacemer
ky
by the sprin
8 attached to the stem and the
is the Hooke's
mt; i acts uy
constant for the spring and x is
ipward,
© scanned with OKEN Scanneryap 11 Drmame Behawor ol Second-Order Sytems
° " au
4 frictional force exerted uy
dt contact of the stem wit
coefficient between ste
‘ward and resulting from the close
h valve packing; C is the friction
m and packing,
Apply Newton’s law and take
pPA~Kx-~c% (4
de Vg,
ow
M)@x Cde
(i) aKa **
Let = M/Kge, 26t = C/K, and K, = A/K and take
@x 5, de
BOE aE xe Kp
The last equation indicates that the stem: posi
second-order dynamics. The transfer function is
(s)_ AK
PO) (MjKegs*+ ¢s +1
1n_x follows inherent
(a.12)
Usually, M << Kg, and as a result, the dynamics of a pneumatic valve
‘an be approximated by that of first-order system.
© scanned with OKEN ScannerChapter 19
Industrial Bioprocesse;
10.1 INTRODUCTION
Teds Bioprocess engineeting ia special branch of chemical engineering, It isthe conglomersed
trathematcs, biology and industrial proces. Ideals with design and development of processes fore
tranufacaring of product from biological materials. For example - pharmaceutical product. aby
ds wih tdying of various biotechnological process used in industries fr large sale producicn
10.2 BASIC CONCEPT OF BIOCHEMICAL PROCESS
‘The basic concept of biochemical process involves following important terms =
10.2.1 Cell
Icis che tin unc off tha can replicate independently. Therefore cell is also called building bloke!
lie. The study of ellis known as cel biology. It consists ofa protoplasm enclosed within a membast
wich, coor ucla and proxi -
10.2.2 Bacteria
{cies living thing that has only one cl. Under the microscope it look ike a ball sod or spi
presen in mos ofthe ol, water aceic hots i i a
is > spring and radioactive waste material. The 0
‘bacteria is known a bcerialogy All bacteria ae not harmful, Some bacteria helps vo digs
fresh body ned viains. iso sed to make hay fond suchas yopur ed cheese. BU
reco and alae arf ht ean oe inet
‘The large seaweed roe rganism that ranges from microscopic size tol sow
Cee ne 2 Ie 2m nao non ar pan ey. Ne wept SE
‘Containing brackish, seasnd waste ant LOSSES for biochemical waste treatment. Outdon! Pe
water are god for growingalga, becauseit needed vast sutfiee
© scanned with OKEN Scannerpoprgess08 gy
soph. They ean not manufacture their own food themselves. They decompose dead matter
se se are parasices. et ie
os Yeast
1 oscar microorganiam sounded by cll wall hough some species ar mull
Fer itince nutes, With ver few exrptions,yeasteproducs by proces known as budding.
jan. Viruses
retell in structure, It is mainly composed of nuke acid and surrounded by protein
feat ly comps a prot
These fthe virus aries ate below the alton of light microscope. Virus exist ony at
Fc highy hospi parasite. Crain mould and many bacteria ae subjected wo invasion by
sew particles.
{03 BIOREACTOR
Akoeacor isa device that support biologically active environment to catied out chemical process
sich involves organisms. Generally, fermenter are called bioreactor. Some example of bioreactors are
jah menter, horizontal fermenter, tower fermenter, ae lie fermenter. A typical bioreactor is shown
ig 1.
sam (Aor mo
sit} (2) godin er
cet egigee ange
Aeypesvate (6) (@) Sight lass ean of ine
(2) Mannate wih gh ass
(10) Agar sha
oun net (42) | (1) Pad bre team
eteg ter cute (13) —» =f
ate oF (18 Coaing cots
(7) Mae
+20 Sample vane
Sou 9)
'
{
(Seng nt at
entng water inet (16) ——+ +:
ou
ro. 101 Borsa
Soran ae common ena ee! consting agar, al coling ci
a va) eK coi pager
qefencions dented
st litains dese in igang contacting elf mises olin soning of
far contl, misng tnd heat ane The fam conta i ached citer by
wae
a
© scanned with OKEN Scanner182
"netrumentaon ane,
mechanical destruction or by chemical intr foam agents. Several other factors such Hey
pressure, shaft power and viscosity are monitored. m
‘Whena pacar opis introduc into a seected growth mati, ga
the particular organism, The growth of the inoculum does not take place inp tea,
proces. The adaptation take place during this period and called lag phase. Fallon
sxe of gow ofthe onanism incteses exponentially for a cen pen "Te rs
ynential
Pres Sime of exponential has thera of growth of th sin desig
bec ofthe eon hat the concentration ofthe nutrients decreases whereas theo
sessbsancsineeases continuously. During this petiod, the rat of groth afore,
‘Tas pevod iced deceleration phase. Afer the deceleration phase the growth of oso,
and the culture enters a stationary phase,
Themis used fr biochemical process grow ina selected medium which spss
‘quired by che organism. There are varity of media exists, but a medi contains a areas
Seoee soucs wae sland micro natin ate most preferable, For example ie poo>
‘ins the gape ised as medium forthe growth of organism,
10.4 STIRRED TANK HEATER
Astredtanheaterisa device that used to
2 oplindrical vessel consisting agit
temperate convolleranda eee
Fig, 10.2, ‘Stemperatu
heat theliqud in atankby an clcicha
ater, sensor and are made of sinless
te converter. A typical industrial tiered unk bo
‘now.
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nicer: klommeltoe toa
ecm fda iin
‘The automatic control for stirred tank heater can be achieved by measuring the outlet fluid
‘using a temperature sensor and. i Me tf a
vance oon esa ea
ett be rng
95 ON-LINE DATA ANALYSIS
pele danas fr state and parameter imation for biochemical proce ia technique which
etd improved cone performance with cahanced roductvig, or example consider 4
Soe The deficiency of online information of bioreactor concerning the process sae impose
sermon or effective contol action. Hence, for bester monitoring and contra of bioreactor online
Teron ofthe process variable i essential
‘The different methods by which stare and parameters ofa bioreactor can be estimated are as
hares:
(Kalman iter
(i) Observer
Gi) Balanced equation
(9) Neural neework
(0) Fussy easoning
(6) Other methods
Inthis section, Kalman filter method is discussed.
105.1 Kalman Fileer
The Kaman fei sed to provide mos favourable eximate of measured and unmeasured sa BF
ean ee faa by combininginfrmaton using matiemata ods of he
reas A eck dag of rate estimation scheme by Kalman fiers shown in i103
Process Measurerent
tsimaton
cual ‘got Emad state
| ra parameter
Process monsuroments
mot Kaan th.
Fig. 10.3 Bock dag
by Kalman filer a any sine i
“munlB Process estimate obtained
Sleeps ie ex consasof wo recursive steps In the Hes SP the process
Thal , il ;
ert aed nthe Kalan fie cos ep te propagted mols eae i
Moi
Propagate the initial state estimate ee
ed wi the procs menuement © Pov 2 Pa can alu del with stochastic
Primate of the Process
so 1 ecan provide accurate P
isadvantages: Ie require much ti
he optimum estimate condition
jme and effort
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